献血对女性身体机能和血液学指标的短期影响。

Temporary impact of blood donation on physical performance and hematologic variables in women.

作者信息

Stangerup Ida, Kramp Nana L, Ziegler Andreas K, Dela Flemming, Magnussen Karin, Helge Jørn Wulff

机构信息

Centre of Healthy Aging, Xlab, Department of Biomedical Sciences, University of Copenhagen, Copenhagen.

Department of Clinical Immunology/Blood Centre, Copenhagen University Hospital, Rigshospitalet/Hvidovre Hospital/Frederiksberg Hospital, Copenhagen, Denmark.

出版信息

Transfusion. 2017 Aug;57(8):1905-1911. doi: 10.1111/trf.14121. Epub 2017 Apr 28.

DOI:10.1111/trf.14121

PMID:28452395

Abstract

BACKGROUND

No former studies have examined how blood donation influences physical performance in women, who due to menstruation may have a slower recovery of performance. Therefore, the aim of this study was to clarify how VO , time trial (TT) performance, and hematologic variables are affected in 18 iron-sufficient (plasma ferritin [P-ferritin] > 30 µg/L) women after a standard 450-mL blood donation.

STUDY DESIGN AND METHODS

VO , TT performance, and blood variables were measured at baseline and 3, 7, 14, 21, and 28 days after blood donation in 18 iron-sufficient women. Anthropometrics were measured at baseline and Day 28.

RESULTS

VO was reduced by 7.5 ± 1.1% from 2973 ± 87 mL/min at baseline to 2765 ± 73 mL/min 3 days after blood donation and remained below baseline until 28 days. The TT performance was reduced by 5.2 ± 1.0% from baseline (868 ± 31 sec) to Day 3 (915 ± 29 sec), but was not different from baseline 14 days after blood donation. Blood hemoglobin (B-Hb) concentration declined by 7.6 ± 2.1% from 8.4 ± 0.1 to 7.8 ± 0.1 mmol/L at baseline and on Day 3, respectively. P-ferritin at baseline was 58 ± 7 µg/L and it decreased (55 ± 3%) to a nadir of 24 ± 3 µg/L 28 days after blood donation and remained lower at 36 ± 4 µg/L after 90 days.

CONCLUSION

VO and B-Hb were only recovered 28 days after a blood donation whereas TT performance was back to baseline 14 days after blood donation.

摘要

背景

以往尚无研究探讨献血对女性身体机能的影响，由于月经原因，女性的机能恢复可能较慢。因此，本研究的目的是阐明18名铁储备充足（血浆铁蛋白[P-铁蛋白]＞30μg/L）的女性在进行标准的450毫升献血后，其最大摄氧量（VO₂）、计时赛（TT）成绩和血液学变量会受到怎样的影响。

研究设计与方法

对18名铁储备充足的女性在献血前及献血后3、7、14、21和28天测量其VO₂、TT成绩和血液变量。在基线和第28天测量人体测量学指标。

结果

VO₂从基线时的2973±87毫升/分钟降至献血后3天的2765±73毫升/分钟，下降了7.5±1.1%，并在28天内一直低于基线水平。TT成绩从基线时的（868±31秒）降至第3天的（915±29秒），下降了5.2±1.0%，但在献血后14天与基线无差异。血液血红蛋白（B-Hb）浓度分别从基线时的8.4±0.1毫摩尔/升降至第3天的7.8±0.1毫摩尔/升下降了7.6±2.1%。基线时P-铁蛋白为58±7μg/L，献血后28天降至最低点24±3μg/L（下降了55±3%），90天后仍较低，为36±4μg/L。