Institute of Medicine, University of Bergen, Bergen, Norway.
Vox Sang. 2010 Apr;98(3 Pt 1):e249-56. doi: 10.1111/j.1423-0410.2009.01270.x. Epub 2009 Oct 28.
Frequent blood donations may lead to a negative iron balance. Iron depletion may be prevented by iron supplementation after whole blood donations. The aim of this study was to compare the short time changes in iron status after donation in two groups randomized to iron supplementation or no additional iron. A second objective was to evaluate the effect of iron supplementation in donors having HFE-variants compared to HFE wild types.
Subjects of both genders (199 women, 200 men) were randomised to receive iron supplementation or no additional iron after donation. Iron status, defined by the concentration of haemoglobin, serum ferritin, soluble transferrin receptor, concentration of haemoglobin in reticulocytes (CHr) and percent hypochrome mature red blood cells, was determined at the start of donation and 8 +/- 2 days after donation. HFE genotyping was performed at reappearance.
There was a significant difference between the two study groups on all the iron status parameters. CHr was an efficient, early marker of ongoing synthesis of haemoglobin. Heterozygosity for the HFE variants C282Y and H63D had no statistically significant influence on the iron status. The donor's baseline serum ferritin value may be basis for an individual iron supplementation regimen, as donors with serum ferritin >50 microg/l do not seem to utilize the iron supplementation, but prefer endogenous iron to restore the loss of haemoglobin.
Iron supplementation had a significant positive impact on the restoration of iron status one week after donation.
频繁献血可能导致铁元素的负平衡。全血捐献后补充铁元素可以预防缺铁。本研究的目的是比较两组随机接受铁补充或不补充铁的个体在捐献后短时间内铁状态的变化。第二个目的是评估铁补充对 HFE 变异体与 HFE 野生型供者的影响。
本研究纳入了 199 名女性和 200 名男性，随机分为接受铁补充或不补充铁的两组。在捐献开始时和捐献后 8±2 天，通过血红蛋白浓度、血清铁蛋白、可溶性转铁蛋白受体、网织红细胞血红蛋白浓度（CHr）和低色素成熟红细胞百分比定义铁状态，并进行 HFE 基因分型。
两组在所有铁状态参数上均存在显著差异。CHr 是正在合成血红蛋白的有效早期标志物。HFE 变异体 C282Y 和 H63D 的杂合性对铁状态没有统计学意义的影响。供者的基线血清铁蛋白值可能是个体铁补充方案的基础，因为血清铁蛋白>50μg/l 的供者似乎不利用铁补充，而是更喜欢内源性铁来恢复血红蛋白的损失。
铁补充对捐献后一周内铁状态的恢复有显著的积极影响。
