Giraldo Newar A, Amariles Pedro, Pino Marín Daniel E, Faus María José
Universidad de Antioquia, Medellín, Colombia.
Universidad de Granada, Granada, España.
Rev Chilena Infectol. 2016 Oct;33(Suppl 1):36-53. doi: 10.4067/S0716-10182016000700005.
To update information about drug interactions in patients with HIV/AIDS.
Comprehensive literature review in MEDLINE/PubMed database from May of 2009 to December of 2014, using the Mesh terms: Anti-retroviral agents and drug interactions or herb-drug interactions or food-drug interactions. Publications with drug interactions in humans, in English or Spanish, and with full text were retrieved. Additionally, citation lists from identified articles were reviewed. The study inclusion was assessed by three independent researchers and by consensus among them when was necessary. Clinical relevance of drug interaction was grouped into four levels according to seriously and probability of occurrence.
Global, 546 different references were retrieved and 243 were selected. In addition 11 further manuscripts were identified in the references of the included articles. Overall, 935 pairs of drug interactions were identified, 95.7% pharmacokinetic (823 by enzyme induction or inhibition and 67 by changes in bioavailability). Of the 935 pairs of drug interactions, 402(43%) were classified as levels 1 or 2.
The most clinically relevant antiretroviral drug interactions are due to pharmacokinetic mechanism, mainly induction or enzyme inhibition, according to previous reviews, the protease inhibitors remain as the antiretrovirals with the highest number of clinical relevant interactions.
更新有关人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）患者药物相互作用的信息。
在MEDLINE/PubMed数据库中进行全面的文献综述，时间跨度为2009年5月至2014年12月，使用的医学主题词为：抗逆转录病毒药物与药物相互作用、草药-药物相互作用或食物-药物相互作用。检索发表的关于人类药物相互作用的英文或西班牙文全文文献。此外，对已识别文章的参考文献列表进行了审查。纳入研究由三名独立研究人员评估，必要时通过他们之间的共识确定。根据严重程度和发生概率，将药物相互作用的临床相关性分为四个等级。
全球共检索到546篇不同参考文献，其中243篇被选中。此外，在所纳入文章的参考文献中又识别出11篇手稿。总体而言，共识别出935对药物相互作用，95.7%为药代动力学相互作用（823对通过酶诱导或抑制，67对通过生物利用度改变）。在这935对药物相互作用中，402对（43%）被归类为1级或2级。
根据以往综述，临床上最相关的抗逆转录病毒药物相互作用是由药代动力学机制引起的，主要是诱导或酶抑制，蛋白酶抑制剂仍然是具有临床相关相互作用数量最多的抗逆转录病毒药物。
