Soper J T, Mutch D G, Chin N, Clarke-Pearson D L, Hammond C B
Southeastern Regional Trophoblastic Disease Center, Duke University Medical Center, Durham, North Carolina.
Obstet Gynecol. 1988 Nov;72(5):796-8.
Between 1968-1984, eight women with renal metastases of gestational trophoblastic disease were treated at the Southeastern Regional Trophoblastic Disease Center. Two (1.3%) of 154 patients referred for primary therapy and six (14%) of 42 patients referred for secondary therapy of metastatic gestational trophoblastic disease had renal metastases. All eight had coexistent pulmonary metastases. Four had central nervous system and other systemic metastases. All had high-risk metastatic gestational trophoblastic disease by assessment of individual risk factors and analysis of a prognostic index score. Three women with limited systemic tumor burden are alive after receiving multiagent chemotherapy and nephrectomy.
1968年至1984年间，东南地区滋养细胞疾病中心收治了8例妊娠滋养细胞疾病肾转移的女性患者。在154例接受初始治疗的患者中，有2例（1.3%）发生肾转移；在42例接受转移性妊娠滋养细胞疾病二次治疗的患者中，有6例（14%）发生肾转移。所有8例患者均合并肺转移。4例有中枢神经系统及其他全身转移。根据个体危险因素评估和预后指数评分分析，所有患者均为高危转移性妊娠滋养细胞疾病。3例全身肿瘤负荷有限的女性在接受多药化疗和肾切除术后仍存活。
