Pisano Simone, Catone Gennaro, Coppola Giangennaro, Carotenuto Marco, Iuliano Raffaella, Tiano Claudia, Montesanto Anna Rita, D'Esposito Vittoria, Miraglia Del Giudice Emanuele, Formisano Pietro, Bravaccio Carmela
1 Department of Mental and Physical Health and Preventive Medicine, Campania University "Luigi Vanvitelli," Naples, Italy .
2 Department of Medicine and Surgery, Clinic of Child and Adolescent Neuropsychiatry, S. Giovanni di Dio and Ruggi d'Aragona Hospital, University of Salerno , Fisciano, Italy .
J Child Adolesc Psychopharmacol. 2017 Nov;27(9):844-848. doi: 10.1089/cap.2016.0203. Epub 2017 Apr 28.
To assess cytokine and chemokine levels in youth experiencing antipsychotic-induced weight gain (AIWG) compared to obese patients, hypothesizing a different "immune signature" between the two kinds of obesity.
We compared a group of youth experiencing AIWG (N 19, mean age 159 months, mean body mass index [BMI] z-score 1.81) and an age-, gender-, and BMI-matched group of untreated obese patients (N 19, mean age 147 months, mean BMI z-score 2) for a wide range of cytokines and chemokines by using a multiplex ELISA test.
Platelet-derived growth factor (PDGF), interleukin (IL)1-β, IL4, IL8, IL9, IL12, IL 17, eotaxin, FGF, GMCSF, IP10, MIP1b, and vascular-endothelial growth factor (VEGF) were significantly lower in the AIWG group, whereas IL13 and RANTES were significantly higher. Controlling for age, sex, and BMI, PDGF, IL4, IL8, IL13, IL17, eotaxin, fibroblast growth factor (FGF), granulocyte-macrophage colony-stimulating factor (GMCSF), IP10, MIP1b, and VEGF remain significantly different.
A clearly different pattern of cytokines distinguishes the two kinds of obesity, suggesting a different immune signature. Interestingly, most of the cytokines and chemokines bearing proinflammatory effects resulted decreased in the AIWG group, whereas IL-13, which holds an immune-modulatory effect, resulted increased.
评估与肥胖患者相比，经历抗精神病药物所致体重增加（AIWG）的青少年体内细胞因子和趋化因子水平，假设两种肥胖存在不同的“免疫特征”。
我们使用多重酶联免疫吸附测定试验，比较了一组经历AIWG的青少年（N = 19，平均年龄159个月，平均体重指数[BMI] z评分1.81）和一组年龄、性别及BMI匹配的未接受治疗的肥胖患者（N = 19，平均年龄147个月，平均BMI z评分2）体内多种细胞因子和趋化因子的水平。
AIWG组中血小板衍生生长因子（PDGF）、白细胞介素（IL）1-β、IL4、IL8、IL9、IL12、IL17、嗜酸性粒细胞趋化因子、成纤维细胞生长因子（FGF）、粒细胞-巨噬细胞集落刺激因子（GMCSF）、干扰素γ诱导蛋白10（IP10）、巨噬细胞炎性蛋白1β（MIP1b）和血管内皮生长因子（VEGF）显著降低，而IL13和调节激活正常T细胞表达和分泌的趋化因子（RANTES）显著升高。在控制年龄、性别和BMI后，PDGF、IL4、IL8、IL13、IL17、嗜酸性粒细胞趋化因子、FGF、GMCSF、IP10、MIP1b和VEGF仍存在显著差异。
细胞因子的明显不同模式区分了两种肥胖，提示存在不同的免疫特征。有趣的是，AIWG组中大多数具有促炎作用的细胞因子和趋化因子水平降低，而具有免疫调节作用的IL-13水平升高。
