a Fédération de Médecine Translationnelle, Service d'Ophtalmologie , Université de Strasbourg - CHU Strasbourg , Strasbourg , France.
b Institut de Parasitologie et de pathologies tropicales, Université de Strasbourg - CHU de Strasbourg , Strasbourg , France.
Ocul Immunol Inflamm. 2018;26(6):964-970. doi: 10.1080/09273948.2017.1310253. Epub 2017 Apr 28.
The host immune reaction during endophthalmitis, studied in particular through the intraocular cytokine network, is essential for the comprehension of the disease and the development of new therapies. Therefore, the purpose of this study was to elucidate the cytokine composition of aqueous humor during endophthalmitis.
In a multicenter case-control study, forty-nine patients with postoperative endophthalmitis and 60 controls (cataract surgery) were included. Visual acuity, local inflammatory grading, medical history and intraocular levels of 27 cytokines and chemokines (measured by multiplex immunoassay) were recorded.
During endophtalmitis, an increase in total cytokines was observed. The raise of Th1 cytokines was particularly noticeable. Chemokines, such as IL-8, MIP-1 β, MCP-1, G-CSF and IP-10, also increased. Pearson's correlation analyses showed a poor visual prognosis with high levels of IL-8, MCP-1 and VEGF and a low level of IL-10 at admission.
An increase in inflammatory cytokines is noticeable during endophthalmitis, with a particular emphasis on IL-8, MCP-1 and VEGF. Targeted anti-inflammatory and anti-VEGF treatments may be of interest in the future.
通过研究眼内细胞因子网络，了解内眼炎期间的宿主免疫反应，对于理解这种疾病和开发新疗法至关重要。因此，本研究旨在阐明内眼炎期间房水的细胞因子组成。
在一项多中心病例对照研究中，纳入 49 例术后眼内炎患者和 60 例对照（白内障手术）。记录视力、局部炎症分级、病史和 27 种细胞因子和趋化因子（通过多重免疫测定法测量）的眼内水平。
在眼内炎期间，观察到总细胞因子增加。Th1 细胞因子的增加尤为明显。趋化因子，如 IL-8、MIP-1β、MCP-1、G-CSF 和 IP-10，也增加了。Pearson 相关性分析显示，入院时高水平的 IL-8、MCP-1 和 VEGF 以及低水平的 IL-10 与较差的视力预后相关。
眼内炎期间炎症细胞因子增加，尤其以 IL-8、MCP-1 和 VEGF 为著。靶向抗炎和抗 VEGF 治疗可能具有未来的应用前景。
