来自海鞘Ascidia virginea的3,7-异喹啉醌。

3,7-Isoquinoline quinones from the ascidian tunicate Ascidia virginea.

作者信息

Possner Sven T, Schroeder Frank C, Rapp Hans Tore, Sinnwell Volker, Franke Stefan, Francke Wittko

机构信息

Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.

Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853-1301, USA.

出版信息

Z Naturforsch C J Biosci. 2017 Jul 14;72(7-8):259-264. doi: 10.1515/znc-2017-0012.

DOI:10.1515/znc-2017-0012

PMID:28453442

Abstract

A new isoquinoline quinone system and its iodinated derivatives were isolated from the ascidian tunicate Ascidia virginea Müller 1776 (Phlebobranchia: Ascidiidae). Structures were elucidated by spectroscopic methods and derivatization reactions. Ascidine A (3,7-dihydro-1,8-dihydroxy-4-(4'-hydroxyphenyl)isoquinoline-3,7-dione (1), ascidine B (3,7-dihydro-1,8-dihydroxy-4-(4'-hydroxy-3'-iodophenyl)isoquinoline-3,7-dione (2), and ascidine C (3,7-dihydro-1,8-dihydroxy-4-(4'-hydroxy-3',5'-diiodophenyl)isoquinoline-3,7-dione (3) represent a novel type of tyrosine-derived alkaloids.

摘要

从海鞘类被囊动物处女海鞘（Ascidia virginea Müller，1776年）（静脉鳃海鞘科：海鞘科）中分离出一种新的异喹啉醌系统及其碘化衍生物。通过光谱方法和衍生化反应阐明了其结构。海鞘素A（3,7-二氢-1,8-二羟基-4-(4'-羟基苯基)异喹啉-3,7-二酮（1）、海鞘素B（3,7-二氢-1,8-二羟基-4-(4'-羟基-3'-碘苯基)异喹啉-3,7-二酮（2）和海鞘素C（3,7-二氢-1,8-二羟基-4-(4'-羟基-3',5'-二碘苯基)异喹啉-3,7-二酮（3）代表了一种新型的酪氨酸衍生生物碱。