腺样囊性癌异位分泌生长激素释放激素（GHRH）和促肾上腺皮质激素（ACTH）导致肢端肥大症，并伴有垂体梗死。
Ectopic release of GHRH and ACTH from an adenoid cystic carcinoma resulting in acromegaly and complicated by pituitary infarction.
作者信息
Southgate H J, Archbold G P, el-Sayed M E, Wright J, Marks V
机构信息
Department of Clinical Biochemistry, St. Luke's Hospital, Guildford, Surrey.
出版信息
Postgrad Med J. 1988 Feb;64(748):145-8. doi: 10.1136/pgmj.64.748.145.
Abstract
A 23 year old man presented with a tumour mass in the lung. Subsequent investigation showed ectopic secretion of adrenocorticotrophic hormone (ACTH) and growth hormone releasing hormone (GHRH) from an adenoid cystic carcinoma. The patient progressed to show the clinical effects of long term exposure to high blood levels of both growth hormone and cortisol. The case was complicated by pituitary infarction. The very high blood levels of ACTH, growth hormone (GH) and GHRH proved resistant to treatment with the somatostatin analogue, SMS 201-995, and a possible side effect of the drug is reported. To our knowledge this is the first reported case of ectopic hormone secretion by an adenoid cystic carcinoma.
摘要
一名23岁男性因肺部肿瘤肿块前来就诊。后续检查显示，腺样囊性癌异位分泌促肾上腺皮质激素（ACTH）和生长激素释放激素（GHRH）。该患者逐渐出现长期暴露于高血生长激素和皮质醇水平的临床效应。病例并发垂体梗死。促肾上腺皮质激素、生长激素（GH）和生长激素释放激素的极高血水平对生长抑素类似物SMS 201-995治疗有抵抗，且报告了该药物可能的副作用。据我们所知，这是首例报道的腺样囊性癌异位激素分泌病例。
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J Clin Endocrinol Metab. 1960 Dec;20:1539-60. doi: 10.1210/jcem-20-12-1539.
2
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3
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