Cohen Zoya, Maimon Yair, Samuels Noah, Berger Raanan
Tal Center for Integrative Oncology, Institute of Oncology, Sheba Medical Center, 52621 Ramat Gan, Israel.
Institute of Oncology, Sheba Medical Center, 52621 Ramat Gan, Israel.
Oncol Lett. 2017 Apr;13(4):2642-2648. doi: 10.3892/ol.2017.5747. Epub 2017 Feb 17.
Numerous botanicals have been shown to exhibit and anticancer activity, some of which is the result of the induction of reactive oxygen species (ROS) in cancer cells with a high ROS content. The present study compared sensitivities to a series of botanicals among cancer cell lines, using an XTT viability test, in order to create a specific cancer-herb profile. Of the 27 botanicals screened, 10 exhibited a cytotoxic effect, 7 of which were ROS-mediated. The sensitivity profiles of the ROS-inducing botanicals in 10 cancer cell lines were similar, unlike 3 cytotoxic ROS-independent botanicals that displayed divergent botanical-specific profiles. The correlation between sensitivity profiles of ROS-inducing botanicals suggests a common mechanism of action, in contrast to the varied mechanism of ROS-independent botanicals. This implies that the investigation of the anticancer activity of botanicals should start with the examination of ROS-mediated activity. Further investigation of ROS sensitivity among various tumor types is required in order to guide research into developing evidence-based guidelines in the use of botanicals for cancer treatment.
许多植物提取物已被证明具有抗癌活性，其中一些是由于在具有高活性氧（ROS）含量的癌细胞中诱导活性氧而产生的。本研究使用XTT活力测试比较了一系列植物提取物在癌细胞系中的敏感性，以建立特定的癌症-草药谱。在筛选的27种植物提取物中，有10种表现出细胞毒性作用，其中7种是由ROS介导的。与3种不依赖ROS的细胞毒性植物提取物显示出不同的植物特异性谱不同，诱导ROS的植物提取物在10种癌细胞系中的敏感性谱相似。诱导ROS的植物提取物的敏感性谱之间的相关性表明其作用机制相同，这与不依赖ROS的植物提取物的多种作用机制形成对比。这意味着对植物提取物抗癌活性的研究应从检查ROS介导的活性开始。为了指导关于开发基于证据的植物提取物用于癌症治疗指南的研究，需要进一步研究各种肿瘤类型对ROS的敏感性。
