WR-2721、16,16-二甲基前列腺素E2以及这两种药物的组合对小鼠在裂变中子-γ射线混合照射（n:γ = 1:1）下的保护作用。
Protection of mice against mixed fission neutron-gamma (n: gamma = 1:1) irradiation by WR-2721, 16,16-dimethyl PGE2, and the combination of both agents.
作者信息
Steel L K, Walden T L, Hughes H N, Jackson W E
机构信息
Radiation Biochemistry, Department Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20814-5145.
出版信息
Radiat Res. 1988 Sep;115(3):605-8.
The survival of mice after whole-body exposure to a modified fission neutron-gamma field (n: gamma = 1:1) was used to examine radiation protection by WR-2721, 16,16-dimethyl PGE2(DiPGE2), and the combination of both agents. Administration of WR-2721 (453 mg/kg) increased the LD50/30 from 5.24 to 7.17 Gy (DMF = 1.37), whereas pretreatment with DiPGE2 (1.6 mg/kg) increased the LD50/30 to 5.77 Gy (dose modification factor (DMF) = 1.10). The combination of 453 mg/kg WR-2721 and 0.4 mg/kg DiPGE2 resulted in an LD50/30 of 7.33 Gy, yielding a DMF of 1.39. However, no significant difference in protection was obtained with the combination of the two agents compared to that seen with WR-2721 alone.
通过将小鼠全身暴露于改良的裂变中子 - 伽马场（n:γ = 1:1）后的存活率，来检测WR - 2721、16,16 - 二甲基前列腺素E2（DiPGE2）以及这两种药物联合使用时的辐射防护作用。给予WR - 2721（453 mg/kg）可使LD50/30从5.24 Gy提高到7.17 Gy（剂量修正因子（DMF）= 1.37），而用DiPGE2（1.6 mg/kg）预处理可使LD50/30提高到5.77 Gy（剂量修正因子（DMF）= 1.10）。453 mg/kg的WR - 2721与0.4 mg/kg的DiPGE2联合使用时，LD50/30为7.33 Gy，剂量修正因子为1.39。然而，与单独使用WR - 2721相比，两种药物联合使用时在防护效果上没有显著差异。
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