Hermann G, Janus C, Schwartz I S, Papatestas A, Hermann D G, Rabinowitz J G
Department of Radiology, Mount Sinai Hospital, New York, NY 10029-6574.
Radiology. 1988 Nov;169(2):321-4. doi: 10.1148/radiology.169.2.2845470.
This study evaluates the mammographic findings in 352 patients, aged 30-85 years, who underwent spot localization and biopsy for evaluation of nonpalpable breast abnormalities. Malignancy was found at biopsy in 114 cases. The mammographic appearance (specifically, whether grouped microcalcifications, mass, or both were present) was correlated with patient age and histologic findings (specifically, whether the pathologic changes were infiltrating or noninfiltrating in nature). The prevalence of malignant conditions increased directly with age. The presence of grouped microcalcifications as the sole indicator of malignancy was seen in 100% (seven of seven) of the patients in the 30-39-year age group, 64% (18 of 28) in the 40-49-year age group, 37% (11 of 30) in the 50-59-year age group, 30% (seven of 23) in the 60-69-year age group, and 23% (six of 26) in the 70-85-year age group. Of the 49 tumors that were manifested solely as microcalcifications, 34 (69%) were noninfiltrating. The finding of grouped microcalcifications should be aggressively investigated, since it may indicate noninfiltrating carcinoma in an early stage, when the potential for cure is greatest.
本研究评估了352例年龄在30至85岁之间的患者的乳腺钼靶检查结果，这些患者因不可触及的乳腺异常接受了定位活检。活检发现114例为恶性肿瘤。乳腺钼靶表现（具体而言，是否存在成簇微小钙化、肿块或两者皆有）与患者年龄和组织学结果（具体而言，病理改变在本质上是浸润性的还是非浸润性的）相关。恶性疾病的患病率随年龄直接增加。成簇微小钙化作为恶性肿瘤唯一指标的情况在30至39岁年龄组的患者中占100%（7例中的7例），40至49岁年龄组中占64%（28例中的18例），50至59岁年龄组中占37%（30例中的11例），60至69岁年龄组中占30%（23例中的7例），70至85岁年龄组中占23%（26例中的6例）。在仅表现为微小钙化的49个肿瘤中，34个（69%）为非浸润性。发现成簇微小钙化应积极进行检查，因为它可能表明早期非浸润性癌，此时治愈的可能性最大。
