Marie Solène, Cisternino Salvatore, Buvat Irène, Declèves Xavier, Tournier Nicolas
Imagerie Moléculaire In Vivo, IMIV, CEA, INSERM, CNRS, Université Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay, France; AP-HP, Hôpital Bicêtre, Pharmacie Clinique, Le Kremlin Bicêtre, France; Faculté de Pharmacie, Université Paris-Sud, Châtenay-Malabry, France.
Variabilité de réponse aux psychotropes, INSERM, U1144, Paris, France; Faculté de pharmacie, Université Paris Descartes, UMR-S 1144, Paris, France.
J Pharm Sci. 2017 Sep;106(9):2335-2344. doi: 10.1016/j.xphs.2017.04.031. Epub 2017 Apr 25.
Transporters of the solute carrier O (SLCO) family, former organic anion-transporting polypeptides, are now recognized as key players in pharmacokinetics. Imaging is increasingly regarded as a relevant method to elucidate and decipher the intrinsic role of SLCO in controlling drug disposition in plasma and tissues. Current research in this representative field of translational research is based on different imaging modalities including nuclear imaging, such as single-photon emission computed tomography or positron emission tomography, and magnetic resonance imaging. Imaging modalities can be compared in terms of sensitivity, quantitative properties, spatial resolution, variety of ligands, and radiation exposure. All these approaches rely on the use of SLCO substrates that are detected using corresponding modalities. The present review aims at reporting and comparing the imaging probes that have been proposed to study SLCO-transport function, in terms of in vitro specificity, in vivo behavior, and clinical validation.
溶质载体O（SLCO）家族的转运蛋白，前身为有机阴离子转运多肽，现在被认为是药代动力学的关键参与者。成像越来越被视为一种相关方法，用于阐明和解读SLCO在控制血浆和组织中药物处置方面的内在作用。该转化研究代表性领域的当前研究基于不同的成像方式，包括核成像，如单光子发射计算机断层扫描或正电子发射断层扫描，以及磁共振成像。成像方式可以在灵敏度、定量特性、空间分辨率、配体种类和辐射暴露方面进行比较。所有这些方法都依赖于使用通过相应方式检测的SLCO底物。本综述旨在报告和比较已提出的用于研究SLCO转运功能的成像探针，包括体外特异性、体内行为和临床验证。
