Yamada R, Tsuji K, Kishi K, Suwa K, Mitsuzane K, Tanaka K, Satoh M, Kawabata M, Maeda M
Department of Radiology, Wakayama Medical College, Japan.
Radiat Med. 1988 Mar-Apr;6(2):79-84.
The following studies were performed to develop a new technique of hyperthermia by vascular catheterization for the treatment of malignant neoplasm. A balloon catheter was inserted into the artery of a cancer-affected organ and inflation of the balloon temporarily occluded the artery, after which an anticancer drug solution warmed to 45 degrees C was infused. The purpose of this technique was to enable the solution to arrive at the affected area undiluted by blood. It would then remain in the organ and act on the lesion. When OK-432 was intravenously administered to induce pyrexia of 40 degrees C, followed by the above-mentioned arterial infusion, it was expected that the effects of hyperthermia and chemotherapy would be synergistic. In cases of liver cancer and urinary bladder cancer subjected to the arterial infusion of warmed anticancer drugs, however, the temperature in the hepatic vein increased by only 0.5 degree C while that in urethra near the tumor increased by only 1 degree C. In the future, further improvement needs to be made to obtain effective local heating with this technique.
进行了以下研究以开发一种通过血管插管进行热疗的新技术，用于治疗恶性肿瘤。将球囊导管插入受癌症影响器官的动脉中，球囊充气会暂时阻断动脉，之后注入加热至45摄氏度的抗癌药物溶液。该技术的目的是使溶液在未被血液稀释的情况下到达受影响区域。然后它会留在器官中并作用于病变部位。当静脉注射OK - 432诱导40摄氏度的发热，随后进行上述动脉灌注时，预计热疗和化疗的效果会产生协同作用。然而，在对肝癌和膀胱癌进行温热抗癌药物动脉灌注的病例中，肝静脉中的温度仅升高了0.5摄氏度，而肿瘤附近尿道中的温度仅升高了1摄氏度。未来，需要进一步改进以通过该技术获得有效的局部加热。
