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康莱特通过抑制 NF-κΒ 和上调连接蛋白 43 使结直肠癌细胞对紫杉醇敏感。

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation.

机构信息

Tianjin Union Medical Center, Tianjin, 300121, China.

Advanced Studies in Genomics, Proteomics, and Bioinformatics, University of Hawaii at Manoa 2538 McCarthy Mall, Snyder Hall, Honolulu, HI, 96822, USA.

出版信息

Sci Rep. 2017 Apr 28;7(1):1280. doi: 10.1038/s41598-017-01480-2.

DOI:10.1038/s41598-017-01480-2
PMID:28455529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5430786/
Abstract

Taxol, a first-line anti-tumour drug, has low effectiveness against colorectal cancer. Combination with other agents is an effective strategy to enhance Taxol cytotoxicity. Kanglaite injection is an extract from Coix lacryma-jobi seed and is usually combined with other agents to treat cancer. The aim of this study was to investigate the treatment effect of Taxol combined with Kanglaite on colorectal cancer cell lines. Kanglaite pretreatment followed by Taxol treatment was found to show the best synergism among all combination strategies. This combination also resulted in the smallest tumour volume in a Balb/c mice model. Kanglaite inhibited the expression of nuclear factor (NF)-κΒ and upregulated that of connexin 43, both of which sensitized cancer cells to Taxol. Moreover, Kanglaite increased many cellular variations caused by Taxol, including tubulin polymerization, caspase-3 cleavage, and upregulated expression of survivin and cyclin B1. These results suggest that Kanglaite pretreatment may increase the effect of Taxol on colorectal cancer.

摘要

紫杉醇是一种一线抗肿瘤药物，对结直肠癌的疗效较低。与其他药物联合使用是增强紫杉醇细胞毒性的有效策略。康莱特注射液是薏苡仁的提取物，通常与其他药物联合用于治疗癌症。本研究旨在探讨紫杉醇联合康莱特治疗结直肠癌细胞系的疗效。康莱特预处理后再用紫杉醇处理显示出所有联合策略中最好的协同作用。这种组合还导致 Balb/c 小鼠模型中的肿瘤体积最小。康莱特抑制核因子 (NF)-κΒ 的表达并上调连接蛋白 43 的表达，这两者均使癌细胞对紫杉醇敏感。此外，康莱特增加了紫杉醇引起的许多细胞变化，包括微管聚合、半胱天冬酶-3 切割以及survivin 和细胞周期蛋白 B1 的上调表达。这些结果表明，康莱特预处理可能会增加紫杉醇对结直肠癌的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/c11dcb1713e0/41598_2017_1480_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/a5d9af2c5441/41598_2017_1480_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/05f23c4cda84/41598_2017_1480_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/d96402d340ad/41598_2017_1480_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/21b2620246b9/41598_2017_1480_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/87cb5408411b/41598_2017_1480_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/c11dcb1713e0/41598_2017_1480_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/a5d9af2c5441/41598_2017_1480_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/05f23c4cda84/41598_2017_1480_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/d96402d340ad/41598_2017_1480_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/21b2620246b9/41598_2017_1480_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/87cb5408411b/41598_2017_1480_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a4/5430786/c11dcb1713e0/41598_2017_1480_Fig6_HTML.jpg

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