Kanakaris Nikolaos K, Anthony Christopher, Papasotiriou Antonios, Giannoudis Peter V
Clinical Lead of Major Trauma Services, Leeds General Infirmary, Clarendon Wing, Level D, LS13EX, Leeds, West Yorkshire, UK.
Trauma and Orthopaedics Yorkshire and Humber Deanery, Leeds Teaching Hospitals NHS Trust, UK.
Injury. 2017 Jun;48 Suppl 1:S10-S14. doi: 10.1016/j.injury.2017.04.017. Epub 2017 Apr 26.
Intramedullary nailing, as the gold standard stabilisation method of most long bones, has been tailed by its extensive use as the basic tool of investigating the immune response to trauma in many large and small animal models, as well as at the clinical setting. Over the last few decades a complex map of interactions between pro and anti-inflammatory pathways has been the result of these significant global research efforts. Parallel to the evolution of modern nailing and reaming techniques, significant developments at the fields of other disciplines relevant to trauma care, has improved the contemporary management of injured patients, challenging previous concepts and altering clinical barriers. The current article aims to summarise the current understanding of the effect of instrumenting the medullary canal after trauma, and hint on potential future directions.
髓内钉固定作为大多数长骨的金标准稳定方法，由于在许多大小动物模型以及临床环境中被广泛用作研究创伤免疫反应的基本工具，一直备受关注。在过去几十年中，这些重大的全球研究努力已经绘制出了促炎和抗炎途径之间相互作用的复杂图谱。与现代髓内钉和扩髓技术的发展并行的是，创伤护理相关其他学科领域的重大进展改善了当代创伤患者的管理，挑战了以往的观念并改变了临床障碍。本文旨在总结目前对创伤后髓腔置管影响的认识，并提示潜在的未来方向。
