Zhang Yi, Wu Peng, Feng Luzhao, Yang Peng, Pan Yang, Feng Shuo, Qin Ying, Zheng Jiandong, Puig-Barberà Joan, Muscatello David, MacIntyre Raina, Cowling Benjamin J, Yu Hongjie, Wang Quanyi
Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing, China; School of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
Vaccine. 2017 May 25;35(23):3129-3134. doi: 10.1016/j.vaccine.2017.03.084. Epub 2017 Apr 26.
Vaccination is recommended to prevent influenza virus infection and associated complications. This study aimed to estimate the influenza vaccine effectiveness (VE) against hospitalization in the 2015/16 season in Beijing.
Patients who were hospitalized in the 5 study hospitals between 1 Oct 2015 and 15 May 2016 were recruited. Influenza vaccination status was obtained for PCR-confirmed influenza patients and the selected controls who tested negative for the virus. Conditional logistic regression was used to estimate the influenza VE matching by calendar week, and adjusting for age, study sites, underlying medical conditions, smoking status, and hospital admissions over the past 12months.
The overall VE was -37.9% (95% CI: -103.3, 6.5) against laboratory-confirmed influenza-associated hospitalization. The 2015-16 seasonal vaccine was had -61.9% (95% CI: -211.9, 15.9), -5.4% (95% CI: -108.1, 46.6) and -45.2% (95% CI: -152.6, 16.5) effectiveness to prevent infection from A(H1N1)pdm09, A(H3N2) and influenza B, respectively.
Influenza vaccination did not show effective protection against hospitalization with influenza in 2015/16 season in Beijing.
建议接种疫苗以预防流感病毒感染及相关并发症。本研究旨在评估2015/16赛季北京地区流感疫苗对住院治疗的有效性（VE）。
招募了2015年10月1日至2016年5月15日期间在5家研究医院住院的患者。获取了经PCR确诊的流感患者以及病毒检测呈阴性的选定对照的流感疫苗接种状况。采用条件逻辑回归按日历周估算流感疫苗有效性，并对年龄、研究地点、基础疾病、吸烟状况以及过去12个月内的住院情况进行调整。
针对实验室确诊的流感相关住院治疗，总体疫苗有效性为-37.9%（95%置信区间：-103.3, 6.5）。2015 - 16季节性疫苗对预防A(H1N1)pdm09、A(H3N2)和乙型流感感染的有效性分别为-61.9%（95%置信区间：-211.9, 15.9）、-5.4%（95%置信区间：-108.1, 46.6）和-45.2%（95%置信区间：-152.6, 16.5）。
2015/16赛季在北京，流感疫苗接种对预防流感住院治疗未显示出有效保护作用。
