Bartus K, Podolec J, Lee R J, Kapelak B, Sadowski J, Bartus M, Oles K, Ceranowicz P, Trabka R, Litwinowicz R
Department of Cardiovascular Surgery and Transplantology, Jagiellonian University, Collegium Medicum, John Paul II Hospital, Cracow, Poland.
Department of Interventional Cardiology, Jagiellonian University, Collegium Medicum, John Paul II Hospital, Cracow, Poland.
J Physiol Pharmacol. 2017 Feb;68(1):117-123.
Percutaneous left atrial appendage closure is an alternative treatment for stroke and systemic thromboembolism risk reduction in non-valvular atrial fibrillation (AF). However, the neurohormonal impact of epicardial exclusion of the left atrial appendage (LAA) with the LARIAT procedure is unknown. Evaluation of changes in atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels in AF patients underwent percutaneous LAA suture ligation. Sixty six patients underwent successfully percutaneous LAA suture ligation using LARIAT device. The level of ANP and BNP was measured before and 3 months after procedure. Mean ANP level before procedure was 249 ± 77 pg/mL (range from 95 pg/mL to 503 pg/mL) and mean BNP level was 481 ± 517 pg/mL (range from 34 pg/mL to 2508 pg/mL). Three months after procedure mean ANP level was 249 ± 79 pg/mL (range from 98 pg/mL to 492 pg/mL) and mean BNP level was 495 ± 526 pg/mL (range from 52 pg/mL to 2420 pg/mL). At 3 months follow up after percutaneous LAA suture ligation there were no significant differences in ANP and BNP levels.
经皮左心耳封堵术是降低非瓣膜性心房颤动（AF）患者中风和全身性血栓栓塞风险的一种替代治疗方法。然而，LARIAT手术经心外膜排除左心耳（LAA）对神经激素的影响尚不清楚。对接受经皮左心耳缝合结扎术的房颤患者的心房利钠肽（ANP）和脑利钠肽（BNP）水平变化进行评估。66例患者成功使用LARIAT装置进行了经皮左心耳缝合结扎术。在手术前和术后3个月测量ANP和BNP水平。术前平均ANP水平为249±77 pg/mL（范围为95 pg/mL至503 pg/mL），平均BNP水平为481±517 pg/mL（范围为34 pg/mL至2508 pg/mL）。术后3个月，平均ANP水平为249±79 pg/mL（范围为98 pg/mL至492 pg/mL），平均BNP水平为495±526 pg/mL（范围为52 pg/mL至2420 pg/mL）。在经皮左心耳缝合结扎术后3个月的随访中，ANP和BNP水平无显著差异。
