利用MEROPS数据库研究溶酶体肽酶、其抑制剂和底物。
Using the MEROPS Database for Investigation of Lysosomal Peptidases, Their Inhibitors, and Substrates.
作者信息
Rawlings Neil D
机构信息
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
出版信息
Methods Mol Biol. 2017;1594:213-226. doi: 10.1007/978-1-4939-6934-0_14.
This chapter describes how to retrieve data on lysosomal peptidases from the MEROPS database for proteolytic enzymes, their substrates and inhibitors ( http://merops.sanger.ac.uk ). Features described in this chapter include the summary page, pages for structure, interactions with inhibitors, substrates, literature and involvement in physiological pathways, and how to download data from the MEROPS FTP site. The lysosomal peptidase legumain is used as an example.
本章介绍如何从蛋白酶、其底物和抑制剂的MEROPS数据库（http://merops.sanger.ac.uk）中检索溶酶体肽酶的数据。本章描述的功能包括摘要页面、结构页面、与抑制剂的相互作用页面、底物页面、文献页面以及在生理途径中的参与情况页面，以及如何从MEROPS FTP站点下载数据。以溶酶体肽酶豆球蛋白为例进行说明。
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