Lu Yang, Yang Yang, He Xin, Dong Shangwen, Wang Wanhua, Wang Donghao, Zhang Peng
Department of Intensive Care Unit, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Department of Anesthesia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Am J Emerg Med. 2017 Oct;35(10):1480-1484. doi: 10.1016/j.ajem.2017.04.056. Epub 2017 Apr 27.
Esmolol is a highly selective beta 1 receptor blocker with various effects such as slowing heart rate, lowering blood pressure and reducing myocardial oxygen consumption. However, few studies have reported the use of beta blockers in sepsis with multiple organ dysfunctions. This study aimed to investigate the effects of esmolol on reducing apoptosis and inflammation in early sepsis rats with abdominal infection.
Rats were randomly divided into sham operation group, sepsis group, antibiotic group, Esmolol + antibiotic group with low, median and high dose Esmolol (L group, M group and H group). Values between two or more groups were compared by independent t-tests.
In the liver and kidney, we found inflammatory infiltration in sepsis group while pathological aspects reduced in L, M and H groups. Bcl-2 mRNA and protein levels increased while Bax mRNA and protein levels decreased in the liver and kidney of L, M and H groups. Serum IL-6, HMGB-1 and TNF-α levels decreased but IL-10 level increased in L, M and H groups, compared to sepsis group. Compared to sepsis and antibiotic groups, the levels of myocardial enzymes were lower in L, M and H groups.
The administration of esmolol in early sepsis may reduce inflammation, inhibit apoptosis and protect key organs.
艾司洛尔是一种高度选择性的β1受体阻滞剂，具有减慢心率、降低血压和减少心肌耗氧量等多种作用。然而，很少有研究报道β受体阻滞剂在伴有多器官功能障碍的脓毒症中的应用。本研究旨在探讨艾司洛尔对腹部感染早期脓毒症大鼠减少细胞凋亡和炎症的作用。
将大鼠随机分为假手术组、脓毒症组、抗生素组、低、中、高剂量艾司洛尔+抗生素组（L组、M组和H组）。两组或多组之间的值采用独立t检验进行比较。
在肝脏和肾脏中，我们发现脓毒症组有炎症浸润，而L组、M组和H组的病理情况有所减轻。L组、M组和H组肝脏和肾脏中Bcl-2 mRNA和蛋白水平升高，而Bax mRNA和蛋白水平降低。与脓毒症组相比，L组、M组和H组血清IL-6、HMGB-1和TNF-α水平降低，但IL-10水平升高。与脓毒症组和抗生素组相比，L组、M组和H组心肌酶水平较低。
在脓毒症早期给予艾司洛尔可能减轻炎症、抑制细胞凋亡并保护关键器官。
