化痰祛湿方对非酒精性脂肪性肝病大鼠肝损伤的保护作用
Protective effect of Hua Tan Qu Shi decoction against liver injury in rats with nonalcoholic fatty liver disease.
作者信息
Zhao Shi Peng, Wu Zhi Sheng, Chen Yu, Liang Xue, Bao Lei, Li Pin, Sun Ran Ran, Wu Yan Ling, Li Ling Ru, Wang Qi
机构信息
Center for Studies in Constitution Research of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.
Beijing University of Chinese Medicine, Beijing, 100102, China; Beijing Key Laboratory for Basic and Development Research on Chinese Medicine, Beijing, 100102, China; Key Laboratory of TCM-information Engineering of State Administration of TCM, Beijing, China.
出版信息
Biomed Pharmacother. 2017 Jul;91:181-190. doi: 10.1016/j.biopha.2017.04.099. Epub 2017 Apr 28.
BACKGROUND
Nonalcoholic fatty liver disease (NAFLD), is currently a worldwide health problem. None of the existing treatment medications had got a satisfactory effect. Hua Tan Qu Shi (HTQS) decoction is a Chinese herbal formula, which has been used clinically to treat NAFLD for years. However, the underlying mechanisms are still unclear.
METHODS
High-fat diet (HFD) induced non-alcoholic fatty liver disease rats treated with or without HTQS decoction by gavage for 10 weeks and examined by serology, 24-h albuminuria, histology, immunohistochemistry, and molecular analyses.
背景
非酒精性脂肪性肝病（NAFLD）目前是一个全球性的健康问题。现有的治疗药物均未取得令人满意的效果。化痰祛湿（HTQS）汤是一种中药配方，多年来一直在临床上用于治疗NAFLD。然而，其潜在机制仍不清楚。
方法
用高脂饮食（HFD）诱导非酒精性脂肪性肝病大鼠，通过灌胃给予或不给予HTQS汤10周，并通过血清学、24小时蛋白尿、组织学、免疫组织化学和分子分析进行检测。
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