Fong Sylvia S, Paholpak Pongsatorn, Daianu Madelaine, Deutsch Mariel B, Riedel Brandalyn C, Carr Andrew R, Jimenez Elvira E, Mather Michelle M, Thompson Paul M, Mendez Mario F
Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA; Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, CA, USA; Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Department of Psychiatry, Khon Kaen University, Khon Khaen, Thailand.
Cortex. 2017 Jul;92:81-94. doi: 10.1016/j.cortex.2017.03.019. Epub 2017 Apr 8.
Impaired attribution of animacy (state of living or being sentient) and of agency (capability of intrinsically-driven action) may underlie social behavior disturbances in behavioral variant frontotemporal dementia (bvFTD). We presented the Heider and Simmel film of moving geometric shapes to 11 bvFTD patients, 11 Alzheimer's disease (AD) patients, and 12 healthy controls (HCs) and rated their recorded verbal responses for animacy attribution and agency attribution. All participants had skin conductance (SC) continuously recorded while viewing the film, and all dementia participants underwent magnetic resonance imaging (MRI) for regions of interest. The bvFTD patients, but not the AD patients, were impaired in animacy attribution, compared to the HCs. In contrast, both bvFTD and AD groups were impaired in agency attribution, compared to the HCs, and only the HCs had increasing SC responsiveness during viewing of the film. On MRI analysis of cortical thicknesses, animacy scores significantly correlated across groups with the right pars orbitalis and opercularis; agency scores with the left inferior and superior parietal cortices and the supramarginal gyrus; and both scores with the left cingulate isthmus involved in visuospatial context. These findings suggest that bvFTD is specifically associated with impaired animacy attribution from right inferior frontal atrophy. In contrast, both dementias may have impaired agency attribution from left parietal cortical atrophy and absent SC increases during the film, a sympathetic indicator of attribution of a social "story" to the moving shapes. These findings clarify disease-related changes in social attribution and corroborate the neuroanatomical origins of animacy and agency.
对有生命性（活着或有感知的状态）和能动性（内在驱动行动的能力）的归因受损可能是行为变异型额颞叶痴呆（bvFTD）社会行为障碍的潜在原因。我们向11名bvFTD患者、11名阿尔茨海默病（AD）患者和12名健康对照者（HCs）播放了海德尔和西梅尔的动态几何形状影片，并对他们记录的关于有生命性归因和能动性归因的口头反应进行评分。所有参与者在观看影片时均持续记录皮肤电导率（SC），所有痴呆症参与者均接受了感兴趣区域的磁共振成像（MRI）检查。与HCs相比，bvFTD患者在有生命性归因方面受损，但AD患者没有。相比之下，与HCs相比，bvFTD组和AD组在能动性归因方面均受损，并且只有HCs在观看影片期间皮肤电导率反应性增加。在对皮质厚度进行MRI分析时，有生命性得分在各组中与右侧眶部和 opercularis显著相关；能动性得分与左侧顶叶上下皮质和缘上回相关；两个得分均与参与视觉空间背景的左侧扣带回峡部相关。这些发现表明，bvFTD与右下额叶萎缩导致的有生命性归因受损密切相关。相比之下，两种痴呆症可能都因左侧顶叶皮质萎缩而导致能动性归因受损，并且在影片播放期间皮肤电导率没有增加，皮肤电导率是将社会“故事”归因于移动形状的交感神经指标。这些发现阐明了与疾病相关的社会归因变化，并证实了有生命性和能动性的神经解剖学起源。
