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Better acute graft--host disease outcomes for allogeneic transplant recipients in the modern era: a tacrolimus effect?现代时代同种异体移植受者更好的急性移植物抗宿主病结局：他克莫司的作用？
Haematologica. 2017 May;102(5):806-808. doi: 10.3324/haematol.2017.165266.
2
Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease.异基因造血细胞移植后长期使用西罗莫司与中重度慢性移植物抗宿主病风险降低相关。
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A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation.一项比较环孢素/甲氨蝶呤与他克莫司/西罗莫司作为异基因造血干细胞移植后移植物抗宿主病预防措施的前瞻性随机试验。
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Graft-versus-host disease after radiation therapy in patients who have undergone allogeneic stem cell transplantation: two case reports.异基因干细胞移植患者放疗后发生移植物抗宿主病：两例报告
J Med Case Rep. 2016 Jul 28;10:209. doi: 10.1186/s13256-016-0999-z.
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Bone Marrow Transplant. 2000 Jul;26(1):109-11. doi: 10.1038/sj.bmt.1702471.
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Tacrolimus as monotherapy or combined with minidose methotrexate for graft-versus-host disease prophylaxis after allogeneic peripheral blood stem cell transplantation: long-term outcomes.他克莫司单药治疗或联合小剂量甲氨蝶呤用于异基因外周血干细胞移植后移植物抗宿主病的预防：长期疗效
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Use of intravenous mycophenolate mofetil for graft-versus-host disease prophylaxis in an allogeneic hematopoietic stem cell transplant recipient with an allergic reaction to cyclosporine and tacrolimus.在一名对环孢素和他克莫司过敏的异基因造血干细胞移植受者中，使用静脉注射霉酚酸酯预防移植物抗宿主病。
Bone Marrow Transplant. 2006 Aug;38(3):253-4. doi: 10.1038/sj.bmt.1705422. Epub 2006 Jun 19.
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Successful Second Allogeneic Stem Cell Transplantation From a Sibling Donor for Relapse of Myelodysplastic Syndrome in a Recipient of a Renal Transplant From His Mother: Case Report.一名接受其母亲肾脏移植的患者，因骨髓增生异常综合征复发，成功接受来自同胞供体的第二次异基因干细胞移植：病例报告
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Prebiotics protect against acute graft-versus-host disease and preserve the gut microbiota in stem cell transplantation.益生元可预防急性移植物抗宿主病并保护干细胞移植患者的肠道微生物群。
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本文引用的文献

1
Improved survival after acute graft--host disease diagnosis in the modern era.现代急性移植物抗宿主病诊断后的生存率提高。
Haematologica. 2017 May;102(5):958-966. doi: 10.3324/haematol.2016.156356. Epub 2017 Mar 16.
2
A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation.一项比较环孢素/甲氨蝶呤与他克莫司/西罗莫司作为异基因造血干细胞移植后移植物抗宿主病预防措施的前瞻性随机试验。
Haematologica. 2016 Nov;101(11):1417-1425. doi: 10.3324/haematol.2016.149294. Epub 2016 Aug 4.
3
Improved Treatment-Related Mortality and Overall Survival of Patients with Grade IV Acute GVHD in the Modern Years.近年来，IV 级急性移植物抗宿主病患者与治疗相关的死亡率和总生存率有所改善。
Biol Blood Marrow Transplant. 2016 May;22(5):910-8. doi: 10.1016/j.bbmt.2015.12.024. Epub 2015 Dec 31.
4
Graft-versus-host disease prophylaxis after transplantation: a network meta-analysis.移植后移植物抗宿主病的预防：一项网状Meta分析。
PLoS One. 2014 Dec 8;9(12):e114735. doi: 10.1371/journal.pone.0114735. eCollection 2014.
5
Phase 3 clinical trial of steroids/mycophenolate mofetil vs steroids/placebo as therapy for acute GVHD: BMT CTN 0802.类固醇/霉酚酸酯与类固醇/安慰剂治疗急性移植物抗宿主病的3期临床试验：BMT CTN 0802
Blood. 2014 Nov 20;124(22):3221-7; quiz 3335. doi: 10.1182/blood-2014-06-577023. Epub 2014 Aug 28.
6
Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors.在异体造血细胞移植使用率显著增加、受体年龄较大以及使用非亲缘供体的情况下，患者的生存率得到了显著提高。
J Clin Oncol. 2013 Jul 1;31(19):2437-49. doi: 10.1200/JCO.2012.46.6193. Epub 2013 May 28.
7
Risk factors for acute GVHD and survival after hematopoietic cell transplantation.造血细胞移植后急性移植物抗宿主病的危险因素和生存情况。
Blood. 2012 Jan 5;119(1):296-307. doi: 10.1182/blood-2011-06-364265. Epub 2011 Oct 18.
8
Reduced mortality after allogeneic hematopoietic-cell transplantation.异基因造血细胞移植后的死亡率降低。
N Engl J Med. 2010 Nov 25;363(22):2091-101. doi: 10.1056/NEJMoa1004383.
9
Graft-versus-host disease prophylaxis with tacrolimus and mycophenolate mofetil in HLA-matched nonmyeloablative transplant recipients is associated with very low incidence of GVHD and nonrelapse mortality.在人类白细胞抗原（HLA）匹配的非清髓性移植受者中，使用他克莫司和霉酚酸酯进行移植物抗宿主病（GVHD）预防，与GVHD和非复发死亡率的极低发生率相关。
Biol Blood Marrow Transplant. 2009 Aug;15(8):919-29. doi: 10.1016/j.bbmt.2009.04.004. Epub 2009 Jun 10.
10
Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome.人类白细胞抗原I类和II类高分辨率配型对无关供者骨髓移植结局的影响：人类白细胞抗原C位点错配与移植结局的严重不良影响相关。
Blood. 2004 Oct 1;104(7):1923-30. doi: 10.1182/blood-2004-03-0803. Epub 2004 Jun 10.

Better acute graft--host disease outcomes for allogeneic transplant recipients in the modern era: a tacrolimus effect?

作者信息

Gooptu Mahasweta, Koreth John

机构信息

Division of Hematologic Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Division of Hematologic Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA

出版信息

Haematologica. 2017 May;102(5):806-808. doi: 10.3324/haematol.2017.165266.

DOI:10.3324/haematol.2017.165266
PMID:28458253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5477598/
Abstract
摘要