Nakada Takeo, Akiba Tadashi, Yabe Mitsuo, Tanaka Keiichiro, Nakano Masataka, Suzuki Masafumi, Morikawa Toshiaki
Department of Surgery, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan.
Department of Pathology, Jikei University Kashiwa Hospital, Chiba, Japan.
Ann Thorac Cardiovasc Surg. 2017 Oct 20;23(5):256-261. doi: 10.5761/atcs.cr.16-00247. Epub 2017 May 1.
Thymomas with ring calcifications are very rare and quaint style. Herein, we presented our three cases of thymomas with ring calcifications and reviewed totally 10 cases including 7 cases of previous English literatures. The median age was 53 years. Myasthenia gravis was a complication in 40%. The median maximal diameter was 50 mm. They were diagnosed as pathological type B or had type B component. Based on World Health Organization (WHO) classification, 20%, 60%, and 20% cases were stage I, stage II, and stage III, respectively. Seven ring calcifications were within tumors (inner type) and two cases were outside tumors (outer type). The other had a thymoma arising in the calcic wall of a calcified thymic cyst (miscellaneous type). Four other anterior mediastinal tumors with ring calcification had been reported. We need pathological examinations for a definitive diagnosis. Surgeons should plan surgery because of the possibility of invasive thymomas, or other malignant tumors.
伴有环状钙化的胸腺瘤非常罕见，形态奇特。在此，我们报告了3例伴有环状钙化的胸腺瘤，并对总共10例病例进行了回顾，其中包括7例既往英文文献报道的病例。中位年龄为53岁。40%的患者出现重症肌无力并发症。中位最大直径为50mm。它们被诊断为病理类型B或含有B型成分。根据世界卫生组织（WHO）分类，分别有20%、60%和20%的病例为Ⅰ期、Ⅱ期和Ⅲ期。7处环状钙化位于肿瘤内部（内部型），2例位于肿瘤外部（外部型）。另一例胸腺瘤起源于钙化胸腺囊肿的钙化壁（混合型）。另有4例前纵隔肿瘤伴有环状钙化的报道。明确诊断需要病理检查。由于存在侵袭性胸腺瘤或其他恶性肿瘤的可能性，外科医生应做好手术规划。
