Yano Hirohito, Shinoda Jun, Iwama Toru
Department of Neurosurgery, Gifu University Graduate School of Medicine.
Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Department of Neurosurgery, Kizawa Memorial Hospital.
Neurol Med Chir (Tokyo). 2017 Jul 15;57(7):312-320. doi: 10.2176/nmc.ra.2016-0312. Epub 2017 May 1.
Positron emission tomography (PET) is being increasingly utilized for the management of brain tumors. Herein, we primarily review our previous studies on the use of PET in glioma that utilize three types of tracers: C-methionine (MET), C-choline, and F-fluorodeoxyglucose. These studies included aspects such as tumor behavior, diagnosis, grade of malignancy, spread and invasion, viability, and genetic deletions; moreover, they also evaluated PET as a tool for planning radiation therapy (RT) and determining its outcome. MET-PET in particular is considered to be the most informative for diagnosis and therapeutic decision-making for glioma patients; it is therefore considered crucial for brain tumor therapy. MET-PET is expected to be widely used for brain tumor patients going forward.
正电子发射断层扫描（PET）在脑肿瘤的管理中得到越来越广泛的应用。在此，我们主要回顾我们之前关于PET在胶质瘤中应用的研究，这些研究使用了三种类型的示踪剂：¹¹C-蛋氨酸（MET）、¹¹C-胆碱和¹⁸F-氟脱氧葡萄糖。这些研究涵盖了肿瘤行为、诊断、恶性程度分级、扩散与侵袭、存活情况以及基因缺失等方面；此外，还评估了PET作为规划放射治疗（RT）和确定其疗效的工具。特别是MET-PET被认为对胶质瘤患者的诊断和治疗决策最具信息价值；因此，它被认为对脑肿瘤治疗至关重要。预计MET-PET今后将广泛应用于脑肿瘤患者。
