Gupta Mrinal
Treatwell Skin Centre, Jammu, Jammu and Kashmir, India.
Indian J Pharmacol. 2017 Jan-Feb;49(1):124-126. doi: 10.4103/0253-7613.201020.
Drug-induced leukocytoclastic vasculitis is a small-vessel vasculitis that most commonly manifests with palpable purpuric lesions on gravity-dependent areas. Vasculitis occurs within weeks after initial administration of medication and demonstrates clearance upon withdrawal of medication. Levetiracetam, a pyrrolidone derivative, is used as an adjunctive therapy in patients with refractory focal epilepsy, myoclonic epilepsy, and primary generalized tonic-clonic seizures. We present a case of a 14-year-old female, who developed cutaneous small-vessel vasculitis within 8 days of initiation of levetiracetam. Vasculitis was successfully managed by discontinuation of medication and systemic corticosteroids. This adverse reaction, to the best of our knowledge, has not been previously reported in literature.
药物性白细胞破碎性血管炎是一种小血管血管炎，最常见的表现是在重力依赖部位出现可触及的紫癜性病变。血管炎在首次用药后数周内发生，停药后症状可缓解。左乙拉西坦是一种吡咯烷衍生物，用于难治性局灶性癫痫、肌阵挛癫痫和原发性全身性强直阵挛发作患者的辅助治疗。我们报告一例14岁女性患者，在开始使用左乙拉西坦8天内发生皮肤小血管血管炎。通过停药和全身使用糖皮质激素，血管炎得到成功控制。据我们所知，这种不良反应此前尚未见文献报道。
