Cardiff R D, Aguilar-Cordova E
Department of Pathology, School of Medicine, University of California, Davis 95616.
Anticancer Res. 1988 Sep-Oct;8(5A):925-33.
The mouse mammary tumor model is a well characterized multistep tumor system which has been used to study characteristics of protoneoplastic and neoplastic lesions of the breast. The ability to transplant mammary epithelial tissue or cells into gland cleared fat pads makes this system more powerful and versatile than most tumor models. Transplantability has provided sufficient tissue to allow sequential molecular analysis of protoneoplastic tissue, making studies of clonality and oncogene activation during tumorigenesis possible. It has also been extensively used for the study of a wide range of carcinogenic agents. The recent development of transgenic mice and transgenic mammary gland technologies provide exciting new avenues of research by providing the opportunity for prospective in-vivo studies of carcinogenesis.
小鼠乳腺肿瘤模型是一个特征明确的多步骤肿瘤系统，已被用于研究乳腺原肿瘤性和肿瘤性病变的特征。将乳腺上皮组织或细胞移植到清除了腺体的脂肪垫中的能力，使该系统比大多数肿瘤模型更强大、更通用。可移植性提供了足够的组织，以便对原肿瘤组织进行连续的分子分析，从而使肿瘤发生过程中的克隆性和癌基因激活研究成为可能。它还被广泛用于研究多种致癌剂。转基因小鼠和转基因乳腺技术的最新发展，为致癌作用的前瞻性体内研究提供了机会，从而开辟了令人兴奋的新研究途径。
