Yang Xinyi, Dinehart Matthew S
The Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
University of Arkansas for Medical Sciences, Little Rock, Arkansas.
J Clin Aesthet Dermatol. 2017 Apr;10(4):47-49.
Vismodegib, a potent inhibitor of the hedgehog pathway, is an effective treatment for advanced basal cell carcinoma. More recently, it has become recognized that other oral and topical medications exist that also inhibit this pathway. Multifocal inhibition has been shown to work more efficaciously than a single pathway inhibition when treating melanocytic tumors. The authors report the successful treatment of a patient with advanced basal cell carcinoma using the combination of vismodegib, itraconazole, and imiquimod, each of which inhibits a different part of the hedgehog pathway.
维莫德吉是一种有效的刺猬信号通路抑制剂，是治疗晚期基底细胞癌的有效药物。最近，人们认识到还有其他口服和外用药物也能抑制该信号通路。在治疗黑素细胞肿瘤时，多靶点抑制已被证明比单一信号通路抑制更有效。作者报告了一名晚期基底细胞癌患者使用维莫德吉、伊曲康唑和咪喹莫特联合治疗成功的病例，这三种药物分别抑制刺猬信号通路的不同部分。
