三刺猬通路抑制治疗基底细胞癌
Triple Hedgehog Pathway Inhibition for Basal Cell Carcinoma.
作者信息
Yang Xinyi, Dinehart Matthew S
机构信息
The Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
University of Arkansas for Medical Sciences, Little Rock, Arkansas.
出版信息
J Clin Aesthet Dermatol. 2017 Apr;10(4):47-49.
Abstract
Vismodegib, a potent inhibitor of the hedgehog pathway, is an effective treatment for advanced basal cell carcinoma. More recently, it has become recognized that other oral and topical medications exist that also inhibit this pathway. Multifocal inhibition has been shown to work more efficaciously than a single pathway inhibition when treating melanocytic tumors. The authors report the successful treatment of a patient with advanced basal cell carcinoma using the combination of vismodegib, itraconazole, and imiquimod, each of which inhibits a different part of the hedgehog pathway.
摘要
维莫德吉是一种有效的刺猬信号通路抑制剂，是治疗晚期基底细胞癌的有效药物。最近，人们认识到还有其他口服和外用药物也能抑制该信号通路。在治疗黑素细胞肿瘤时，多靶点抑制已被证明比单一信号通路抑制更有效。作者报告了一名晚期基底细胞癌患者使用维莫德吉、伊曲康唑和咪喹莫特联合治疗成功的病例，这三种药物分别抑制刺猬信号通路的不同部分。
相似文献
1
Triple Hedgehog Pathway Inhibition for Basal Cell Carcinoma.三刺猬通路抑制治疗基底细胞癌
J Clin Aesthet Dermatol. 2017 Apr;10(4):47-49.
2
Vismodegib and the hedgehog pathway: a new treatment for basal cell carcinoma.维莫德吉与刺猬通路：基底细胞癌的一种新疗法。
Clin Ther. 2012 Oct;34(10):2039-50. doi: 10.1016/j.clinthera.2012.08.011. Epub 2012 Oct 1.
3
Vismodegib hedgehog-signaling inhibition and treatment of basal cell carcinomas as well as keratocystic odontogenic tumors in Gorlin syndrome.维莫德吉抑制Hedgehog信号通路及治疗基底细胞癌和戈林综合征中的牙源性角化囊性瘤。
Ann Maxillofac Surg. 2015 Jan-Jun;5(1):14-9. doi: 10.4103/2231-0746.161049.
4
Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma. hedgehog 通路抑制治疗基底细胞癌。
Target Oncol. 2019 Jun;14(3):253-267. doi: 10.1007/s11523-019-00648-2.
5
Sonic Hedgehog Pathway Inhibition in the Treatment of Advanced Basal Cell Carcinoma.Sonic Hedgehog 通路抑制在晚期基底细胞癌治疗中的应用。
Curr Treat Options Oncol. 2019 Nov 26;20(11):84. doi: 10.1007/s11864-019-0683-9.
6
Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib.维莫德吉抑制 Hedgehog 通路对基底细胞癌和头颈部鳞状细胞癌的放射增敏作用。
Int J Mol Sci. 2018 Aug 23;19(9):2485. doi: 10.3390/ijms19092485.
7
Vismodegib: an inhibitor of the Hedgehog signaling pathway in the treatment of basal cell carcinoma.维莫德吉：一种用于治疗基底细胞癌的刺猬信号通路抑制剂。
Ann Pharmacother. 2014 Jan;48(1):99-106. doi: 10.1177/1060028013506696. Epub 2013 Oct 15.
8
A comprehensive review of the role of the hedgehog pathway and vismodegib in the management of basal cell carcinoma.对刺猬信号通路及维莫德吉在基底细胞癌治疗中作用的全面综述。
Curr Med Res Opin. 2015 Apr;31(4):743-56. doi: 10.1185/03007995.2015.1018988. Epub 2015 Mar 17.
9
Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma.晚期基底细胞癌患者中刺猬通路抑制剂相关不良事件的特征与管理
Oncologist. 2016 Oct;21(10):1218-1229. doi: 10.1634/theoncologist.2016-0186. Epub 2016 Aug 10.
10
Vismodegib, itraconazole and sonidegib as hedgehog pathway inhibitors and their relative competencies in the treatment of basal cell carcinomas.维莫德吉、伊曲康唑和索尼德吉作为刺猬信号通路抑制剂及其在治疗基底细胞癌方面的相对效能。
Crit Rev Oncol Hematol. 2016 Feb;98:235-41. doi: 10.1016/j.critrevonc.2015.11.006. Epub 2015 Nov 21.
引用本文的文献
1
Switching Hedgehog inhibitors and other strategies to address resistance when treating advanced basal cell carcinoma.在治疗晚期基底细胞癌时，更换刺猬信号通路抑制剂及其他策略以应对耐药性。
Oncotarget. 2021 Sep 28;12(20):2089-2100. doi: 10.18632/oncotarget.28080.
2
Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma.Wnt 和 Hh 信号通路在基底细胞癌发病机制中的相互作用。
Int J Environ Res Public Health. 2018 Jul 9;15(7):1442. doi: 10.3390/ijerph15071442.
3
Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma. hedgehog 信号通路在骨肉瘤发生发展和转移中的作用及其在骨肉瘤临床治疗中的潜在价值。
Cell Death Dis. 2018 Jun 13;9(6):701. doi: 10.1038/s41419-018-0647-1.
本文引用的文献
1
Multiple facial basal cell carcinomas in xeroderma pigmentosum treated with topical imiquimod 5% cream.用5%咪喹莫特乳膏治疗着色性干皮病中的多发性面部基底细胞癌。
Dermatol Ther. 2015 Jul-Aug;28(4):243-7. doi: 10.1111/dth.12217. Epub 2015 Mar 5.
2
An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma.一位身怀新技能的老朋友：咪喹莫特作为基底细胞癌中刺猬信号通路的新型抑制剂
Oncoscience. 2014 Sep 16;1(9):567-73. doi: 10.18632/oncoscience.80. eCollection 2014.
3
Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma.开放性、探索性 II 期临床试验：口服伊曲康唑治疗基底细胞癌。
J Clin Oncol. 2014 Mar 10;32(8):745-51. doi: 10.1200/JCO.2013.49.9525. Epub 2014 Feb 3.
4
Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib.晚期基底细胞癌患者接受 Hedgehog 通路抑制剂维莫德吉治疗的扩大准入研究。
J Am Acad Dermatol. 2014 Jan;70(1):60-9. doi: 10.1016/j.jaad.2013.09.012. Epub 2013 Nov 1.
5
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists.伊曲康唑和三氧化二砷抑制 Hedgehog 通路的激活和获得性对 smoothened 拮抗剂耐药相关的肿瘤生长。
Cancer Cell. 2013 Jan 14;23(1):23-34. doi: 10.1016/j.ccr.2012.11.017. Epub 2013 Jan 3.
6
Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome.抑制基底细胞痣综合征患者的 hedgehog 通路。
N Engl J Med. 2012 Jun 7;366(23):2180-8. doi: 10.1056/NEJMoa1113538.
7
Efficacy and safety of vismodegib in advanced basal-cell carcinoma.维莫德吉治疗晚期基底细胞癌的疗效和安全性。
N Engl J Med. 2012 Jun 7;366(23):2171-9. doi: 10.1056/NEJMoa1113713.
8
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.伊曲康唑，一种常用的抗真菌药物，可抑制 Hedgehog 通路活性和肿瘤生长。
Cancer Cell. 2010 Apr 13;17(4):388-99. doi: 10.1016/j.ccr.2010.02.027.
9
Basal cell carcinomas: attack of the hedgehog.基底细胞癌：刺猬信号通路的作用
Nat Rev Cancer. 2008 Oct;8(10):743-54. doi: 10.1038/nrc2503.
Zotero 插件