Xia Pu, Xu Xiao-Yan
1 Department of Cell Biology, College of Basic Medical Science, Liaoning Medical University, Jinzhou, P.R. China.
2 Department of Pathophysiology, College of Basic Medical Sciences, China Medical University, Shenyang, P.R. China.
Tumour Biol. 2017 May;39(5):1010428317698373. doi: 10.1177/1010428317698373.
Gastric cancer remains a big health problem in China. Gastric cancer cells contain a small subpopulation of cells that exhibit capabilities of differentiation and tumorigenicity. A putative explanation for ineffective therapy is the presence of cancer stem-like cells. Side population cells, which have cancer stem-like cells' property, are characterized by the high efflux ability of Hoechst 33342 dye. Side population cells have been isolated from gastric cancer cell lines in previous studies. The epithelial-mesenchymal transition is very important in the invasion and metastasis of epithelial-derived cancers. More and more studies showed that gastric cancer stem-like cells possess high invasive ability and epithelial-mesenchymal transition property. A brief overview of the recent advancements in gastric cancer stem-like cells and epithelial-mesenchymal transition will be helpful for providing novel insight into gastric cancer treatment.
胃癌在中国仍然是一个重大的健康问题。胃癌细胞包含一小部分具有分化和致瘤能力的细胞亚群。对于治疗无效的一种推测性解释是癌症干细胞样细胞的存在。具有癌症干细胞样细胞特性的侧群细胞，其特征是对Hoechst 33342染料具有高流出能力。在先前的研究中已从胃癌细胞系中分离出侧群细胞。上皮-间质转化在源自上皮的癌症的侵袭和转移中非常重要。越来越多的研究表明，胃癌干细胞样细胞具有高侵袭能力和上皮-间质转化特性。对胃癌干细胞样细胞和上皮-间质转化的最新进展进行简要概述，将有助于为胃癌治疗提供新的见解。
