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甲状旁腺激素（PTH）和甲状旁腺激素样肽在成骨样细胞中对1,25 - 二羟维生素D3受体的异源上调作用。

Heterologous up-regulation of the 1,25-dihydroxyvitamin D3 receptor by parathyroid hormone (PTH) and PTH-like peptide in osteoblast-like cells.

作者信息

Pols H A, van Leeuwen J P, Schilte J P, Visser T J, Birkenhäger J C

机构信息

Department of Internal Medicine III, Erasmus University Medical School, Rotterdam, The Netherlands.

出版信息

Biochem Biophys Res Commun. 1988 Oct 14;156(1):588-94. doi: 10.1016/s0006-291x(88)80883-0.

DOI:10.1016/s0006-291x(88)80883-0
PMID:2845985
Abstract

1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) receptor content in cultured osteogenic sarcoma cells (UMR-106) was found to be increased after treatment with both bovine and human PTH and human PTH-like peptide (hPLP). The dose dependent increase of receptors was preceded by a dose dependent stimulation of cAMP production. This suggests a role for cAMP as mediator of the PTH- and hPLP-induced 1,25-(OH)2D3 receptor up-regulation. Furthermore, evidence was obtained that new mRNA and de novo receptor synthesis is involved in this heterologous 1,25-(OH)2D3 receptor up-regulation.

摘要

研究发现，用牛甲状旁腺激素（PTH）、人甲状旁腺激素及人甲状旁腺素样肽（hPLP）处理培养的骨肉瘤细胞（UMR-106）后，其1,25-二羟维生素D3（1,25-(OH)2D3）受体含量增加。在受体呈剂量依赖性增加之前，cAMP生成也呈剂量依赖性刺激。这表明cAMP作为PTH和hPLP诱导的1,25-(OH)2D3受体上调的介质发挥作用。此外，有证据表明新的mRNA和从头合成的受体参与了这种异源性1,25-(OH)2D3受体上调。

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