热量限制对老年恒河猴血浆褪黑素水平的影响。
Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques.
作者信息
Aghazadeh-Sanai Nona, Downs Jodi L, Mattison Julie A, Ingram Donald K, Kohama Steven G, Urbanski Henryk F
机构信息
Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.
Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
出版信息
Neurobiol Aging. 2017 Jul;55:213-216. doi: 10.1016/j.neurobiolaging.2017.03.032. Epub 2017 Apr 8.
In this study, we examined the 24-hour plasma melatonin patterns of young adult (∼11 years of age) and old (∼24 years of age) rhesus macaques, and determined how they would be influenced by 30% caloric restriction (CR). Well-defined 24-hour plasma melatonin rhythms were observed in all the males but only the old animals showed significant attenuation of night-time melatonin levels. Moreover, 4.5 years of CR failed to prevent the age-associated decline in plasma melatonin levels in the old males and caused a significant decrease in the young adult males. Similar plasma melatonin rhythms were also observed in all the females but no age-related decline was detected, and 2 years of CR had no obvious effect on plasma melatonin levels. If anything, there was a trend for the CR to decrease melatonin levels in the young adult females. Taken together, the results fail to show any clear benefit of CR on plasma melatonin levels in old rhesus macaques and may even be detrimental to plasma melatonin levels in young adults.
在本研究中，我们检测了年轻成年（约11岁）和老年（约24岁）恒河猴的24小时血浆褪黑素模式，并确定了30%热量限制（CR）对其的影响。在所有雄性恒河猴中均观察到明确的24小时血浆褪黑素节律，但只有老年动物夜间褪黑素水平出现显著下降。此外，4.5年的热量限制未能阻止老年雄性恒河猴血浆褪黑素水平随年龄增长而下降，且导致年轻成年雄性恒河猴血浆褪黑素水平显著降低。在所有雌性恒河猴中也观察到类似的血浆褪黑素节律，但未检测到与年龄相关的下降，且2年的热量限制对血浆褪黑素水平无明显影响。如果有影响的话，热量限制有使年轻成年雌性恒河猴褪黑素水平降低的趋势。综上所述，结果未能显示热量限制对老年恒河猴血浆褪黑素水平有任何明显益处，甚至可能对年轻成年恒河猴的血浆褪黑素水平有害。
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