Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Australia.
Diabetes and Vascular Medicine Unit, Monash Health, Clayton, Australia.
Eur Respir J. 2017 May 1;49(5). doi: 10.1183/13993003.01334-2016. Print 2017 May.
Recent research suggests that women with polycystic ovary syndrome (PCOS) may have a higher prevalence of asthma. However, there are no epidemiological studies aimed primarily at exploring the relationship between PCOS and asthma, and the effect of body mass index (BMI) on this association.This study is a cross-sectional analyses of data from the Australian Longitudinal Study on Women's Health, a large, community-based, prospective study to examine the association between PCOS and asthma in women aged 28-33 years (n=478 PCOS and n=8134 controls).The prevalence of asthma was 15.2% in women with PCOS and 10.6% in women without PCOS (p=0.004). Women with PCOS who had asthma had a trend for a higher BMI compared with women without asthma (29.9±0.9 27.7±0.4 kg·m; p=0.054). Women without PCOS who had asthma had a higher BMI compared with women without asthma (26.4±0.2 24.9±0.1 kg·m; p<0.001). After adjusting for age, BMI and smoking status, PCOS was associated with increased odds of asthma (odds ratio 1.34, 95% CI 1.004-1.79; p=0.047).This study showed both PCOS status and overweight/obese status were independently associated with asthma. Further prospective studies are required to explore the possible mechanisms underpinning the association between asthma and PCOS.
最近的研究表明，多囊卵巢综合征（PCOS）女性患哮喘的比例可能更高。然而，目前还没有主要针对探索 PCOS 与哮喘之间关系的流行病学研究，也没有研究体重指数（BMI）对这种关联的影响。
这项研究是对澳大利亚女性健康纵向研究（一项大型社区为基础的前瞻性研究）数据的横断面分析，旨在检查 28-33 岁女性中 PCOS 和哮喘之间的关联（n=478 例 PCOS 和 n=8134 例对照）。
患有 PCOS 的女性哮喘患病率为 15.2%，未患有 PCOS 的女性哮喘患病率为 10.6%（p=0.004）。与无哮喘的女性相比，患有哮喘的 PCOS 女性 BMI 呈上升趋势（29.9±0.9 与 27.7±0.4kg·m；p=0.054）。与无哮喘的女性相比，患有哮喘的无 PCOS 女性 BMI 更高（26.4±0.2 与 24.9±0.1kg·m；p<0.001）。在调整年龄、BMI 和吸烟状况后，PCOS 与哮喘的患病几率增加相关（比值比 1.34，95%CI 1.004-1.79；p=0.047）。
本研究表明，PCOS 状态和超重/肥胖状态均与哮喘独立相关。需要进一步的前瞻性研究来探讨哮喘和 PCOS 之间关联的潜在机制。
