Juber Nirmin F, Abdulle Abdishakur, AlJunaibi Abdulla, AlNaeemi Abdulla, Ahmad Amar, Leinberger-Jabari Andrea, Al Dhaheri Ayesha S, AlZaabi Eiman, Al-Maskari Fatma, AlAnouti Fatme, Alsafar Habiba, Alkaabi Juma, Wareth Laila Abdel, Aljaber Mai, Kazim Marina, Weitzman Michael, Al-Houqani Mohammad, Hag-Ali Mohammed, Oumeziane Naima, Sherman Scott, Shah Syed M, Almahmeed Wael, Idaghdour Youssef, Loney Tom, El-Shahawy Omar, Ali Raghib
Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Department of Pediatrics, Zayed Military Hospital, Abu Dhabi, United Arab Emirates.
Int J Womens Health. 2023 Feb 15;15:289-298. doi: 10.2147/IJWH.S398651. eCollection 2023.
This study aimed to assess the prevalence of self-reported polycystic ovary syndrome (PCOS) among Emiratis and examine bi-directional associations of PCOS with self-reported chronic diseases, namely: diabetes, asthma, high cholesterol, and high blood pressure.
A cross-sectional analysis was performed using the UAE Healthy Future Study (UAEHFS) data collected from February 2016 to April 2022 involving 1040 Emirati women aged 25-67 years from recruitment centers in the United Arab Emirates (UAE). The bi-directional associations between self-reported PCOS and self-reported chronic diseases were evaluated by establishing temporality based on reported age-at-diagnoses. Firstly, the associations between PCOS (diagnosed at ≥25 years) and chronic diseases (diagnosed at <25 years) were examined, followed by PCOS (diagnosed at <25 years) and chronic diseases (diagnosed at ≥25 years). Finally, a Poisson regression under unadjusted and age-and-body mass index (BMI) adjusted models was performed to obtain the risk ratio (RR) and its 95% confidence interval (CI).
The prevalence of PCOS in this study was 25.9%. Those with asthma and high cholesterol diagnosed at <25 years had increased risks of PCOS diagnosed at ≥25 years (RR = 1.79, 95% CI: 1.17-2.76 for asthma; and RR = 1.61, 95% CI: 1.01-2.59 for high cholesterol), compared to those respective healthier counterparts, after adjusting for age and BMI. No significant association was observed between PCOS diagnosed at <25 years and respective chronic diseases diagnosed at ≥25 years.
PCOS prevalence among Emirati women was high. Asthma and high cholesterol in earlier life were associated with PCOS in later life. Understanding how chronic disease conditions and PCOS are associated in bi-directional ways may improve the surveillance of chronic disease conditions among women with PCOS and may also contribute to more targeted PCOS prevention strategies.
本研究旨在评估阿联酋人群中自我报告的多囊卵巢综合征（PCOS）的患病率，并研究PCOS与自我报告的慢性病（即糖尿病、哮喘、高胆固醇和高血压）之间的双向关联。
采用阿联酋健康未来研究（UAEHFS）的数据进行横断面分析，该数据收集于2016年2月至2022年4月，涉及来自阿拉伯联合酋长国（UAE）招募中心的1040名年龄在25 - 67岁的阿联酋女性。通过根据报告的诊断年龄确定时间顺序，评估自我报告的PCOS与自我报告的慢性病之间的双向关联。首先，研究PCOS（诊断年龄≥25岁）与慢性病（诊断年龄<25岁）之间的关联，然后是PCOS（诊断年龄<25岁）与慢性病（诊断年龄≥25岁）之间的关联。最后，在未调整以及年龄和体重指数（BMI）调整的模型下进行泊松回归，以获得风险比（RR）及其95%置信区间（CI）。
本研究中PCOS的患病率为25.9%。在调整年龄和BMI后，与各自健康的对照组相比，在<25岁时被诊断为哮喘和高胆固醇的患者在≥25岁时被诊断为PCOS的风险增加（哮喘的RR = 1.79，95% CI：1.17 - 2.76；高胆固醇的RR = 1.61，95% CI：1.01 - 2.59）。在<25岁时被诊断为PCOS与在≥25岁时被诊断为各自的慢性病之间未观察到显著关联。
阿联酋女性中PCOS的患病率较高。早年的哮喘和高胆固醇与晚年的PCOS相关。了解慢性病状况和PCOS如何以双向方式关联，可能会改善对PCOS女性慢性病状况的监测，也可能有助于制定更有针对性的PCOS预防策略。
