一名患有先天性额外染色体的患者在肺癌后发生急性非淋巴细胞白血病。
Acute nonlymphocytic leukemia following lung cancer in a patient with a constitutional supernumerary chromosome.
作者信息
Minamihisamatsu M, Gregorio J S, Onozawa Y, Ishihara T
机构信息
Division of Radiation Hazards, National Institute of Radiological Sciences, Chiba, Japan.
出版信息
Cancer Genet Cytogenet. 1988 Oct 15;35(2):263-8. doi: 10.1016/0165-4608(88)90249-x.
PMID:2846147
Abstract
A patient with a constitutional bisatellited supernumerary marker chromosome developed a large cell lung carcinoma and subsequent acute nonlymphocytic leukemia (ANLL) of the M2 type showing an (8;21) translocation and del(9). The ANLL-M2 appeared to be independent of the lung carcinoma. The presence of the supernumerary chromosome might have been associated with the development of the two diseases.
摘要
一名患有体质性双随体额外标记染色体的患者发生了大细胞肺癌，随后又出现了M2型急性非淋巴细胞白血病（ANLL），伴有(8;21)易位和9号染色体缺失。ANLL-M2似乎与肺癌无关。额外染色体的存在可能与这两种疾病的发生有关。
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