基础与转化科学：来自GRAPPA 2016年会的报告。

Basic and Translational Science: A Report from the GRAPPA 2016 Annual Meeting.

作者信息

Krueger James G, Kirkham Bruce, Ritchlin Christopher T

机构信息

From Clinical Investigation, The Rockefeller University, New York; Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, New York, USA; Guy's and St. Thomas' UK National Health Service (NHS) Foundation Trust; King's College London, London, UK.

J.G. Krueger, MD, PhD, D. Martin Carter Professor in Clinical Investigation, The Rockefeller University; B. Kirkham, MD, Consultant Rheumatologist, Guy's and St. Thomas' NHS Foundation Trust, and Professor of Translational Rheumatology, King's College London; C.T. Ritchlin, MD, MPH, Professor of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center.

出版信息

J Rheumatol. 2017 May;44(5):679-683. doi: 10.3899/jrheum.170143.

DOI:10.3899/jrheum.170143

PMID:28461524

Abstract

Rapid advances in effective treatments for psoriasis and psoriatic arthritis (PsA) have emerged from improved understanding of cell subsets and critical mediators that promote tissue inflammation and destruction. More specifically, increased knowledge of innate immunity and the important involvement of cytokines in the interleukin (IL)-23-IL-17 axis as key mediators of psoriatic plaque and joint inflammation in both psoriasis and PsA have led to new theories of immunopathogenesis. Herein we summarize recent discussions on IL-17-related pathways and their relationship to psoriasis and PsA.

摘要

随着对促进组织炎症和破坏的细胞亚群及关键介质的理解不断深入，银屑病和银屑病关节炎（PsA）的有效治疗取得了迅速进展。更具体地说，对固有免疫的认识增加以及细胞因子在白细胞介素（IL）-23-IL-17轴中的重要作用，作为银屑病斑块和银屑病及PsA关节炎症的关键介质，引发了免疫发病机制的新理论。在此，我们总结了近期关于IL-17相关途径及其与银屑病和PsA关系的讨论。