Levine P H, Connelly R R, Milman G, Easton J
Environmental Epidemiology Branch, NCI, Bethesda, MD 20892.
Cancer Detect Prev. 1988;12(1-6):357-62.
Epstein-Barr virus (EBV) is suspected as being etiologically related to nasopharyngeal carcinoma (NPC). Antibodies to EBV antigens have been used in the early detection of NPC and serologic assays are being utilized in the mass screening of high risk populations. While areas of potential application to disease control, such as therapy, are still in the developmental phase, EBV serology has been reported to be of value in the detection of early relapse. Since the data from a series of studies provide conflicting results, however, in this report we review the current information regarding detection of early relapse and describe specific areas that require particular attention if the role of EBV serology in this aspect of NPC control is to be well defined.
爱泼斯坦-巴尔病毒（EBV）被怀疑与鼻咽癌（NPC）存在病因学关联。EBV抗原抗体已用于NPC的早期检测，血清学检测也正在用于高危人群的大规模筛查。虽然EBV在疾病控制方面的潜在应用领域，如治疗，仍处于发展阶段，但据报道EBV血清学在早期复发检测中具有价值。然而，由于一系列研究的数据提供了相互矛盾的结果，在本报告中，我们回顾了有关早期复发检测的当前信息，并描述了如果要明确EBV血清学在NPC控制这一方面的作用则需要特别关注的特定领域。
