一种新型嘧啶基 - 二（二氮杂螺烷）衍生物的抗逆转录病毒活性
Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative.
作者信息
Novoselova E A, Riabova O B, Leneva I A, Nesterenko V G, Bolgarin R N, Makarov V A
机构信息
«NEARMEDIC PLUS» LLC, Aviakonstruktora Mikoyana str. 12, Moscow, 125252, Russia.
A.N. Bach Institute of Biochemestry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, Leninskiy pr. 33-2b, Moscow, 119071, Russia.
出版信息
Acta Naturae. 2017 Jan-Mar;9(1):105-107.
A novel compound, 3,3'-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell's surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses.
合成了一种新型化合物，3,3'-(5-硝基嘧啶-4,6-二基)双-3,12-二氮杂-6,9-二氮鎓二螺[5.2.5.2]十六烷四氯化物二盐酸盐。发现该化合物通过阻断宿主细胞表面特定的硫酸乙酰肝素受体来抑制各种病毒家族的复制。在实验中，发现该化合物对几种HIV逆转录病毒株具有高效性。
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