Lee Kyung Eun, Kim Joong Jae, Jin Hee-Jeong, Lee Siwoo, Shim Eun Bo
Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, Korea.
Mibyeong Research Center, Korea Institute of Oriental Medicine, Daejeon, Korea.
Integr Med Res. 2017 Mar;6(1):88-92. doi: 10.1016/j.imr.2017.01.005. Epub 2017 Jan 18.
Individuals with Mibyeong are difficult to identify. Although extensive research has attempted to introduce an easy and clear method for Mibyeong diagnosis, the indices used to categorize Mibyeong severity are unclear. We hypothesized that individuals with severe Mibyeong have reduced physiological function, thus activating homeostatic regulatory functions and inducing alterations in vascular resistance and capacitance.
Novel indices used to categorize Mibyeong severity based on the cardiovascular system model are described. We analyzed resistance and capacitance values using a simple cardiovascular system model optimally satisfying the measured systolic and diastolic pressures, heart rate, and age.
Clinical data from 509 individuals were examined to test our hypothesis. A statistical analysis revealed that the vascular resistance was lower in individuals with severe Mibyeong symptoms and decreased with increasing Mibyeong severity, whereas the vascular capacitance showed an opposite trend.
We derived indices to categorize Mibyeong severity and tested 509 individuals. An epidemiological analysis revealed that the vascular resistance decreased while the capacitance increased with increasing Mibyeong severity, indicating the validity of the values as Mibyeong indices.
命病患者难以识别。尽管已有大量研究试图引入一种简单明了的命病诊断方法，但用于对命病严重程度进行分类的指标尚不清楚。我们推测，重症命病患者的生理功能下降，从而激活稳态调节功能，并导致血管阻力和容量发生改变。
描述了基于心血管系统模型用于对命病严重程度进行分类的新指标。我们使用一个能最佳拟合所测收缩压、舒张压、心率和年龄的简单心血管系统模型来分析阻力和容量值。
对509名个体的临床数据进行了检验以验证我们的假设。统计分析表明，重症命病症状患者的血管阻力较低，且随着命病严重程度的增加而降低，而血管容量则呈现相反趋势。
我们得出了用于对命病严重程度进行分类的指标，并对509名个体进行了测试。一项流行病学分析表明，随着命病严重程度的增加，血管阻力降低而容量增加，这表明这些值作为命病指标的有效性。
