Amer Hanan M, Abd El Baky Rania S, Nasr Merhan S, Hendawy Laila M, Ibrahim Wessam A, Taha Mohamed O
Division of Endocrinology, Department of Internal Medicine, Ain Shams University Hospital, Cairo, Egypt.
Department of Obstetrics and Gynecology, Ain Shams University Hospital, Cairo, Egypt.
Curr Diabetes Rev. 2018;14(4):389-394. doi: 10.2174/1573399813666170502110559.
Gestational diabetes mellitus is any degree of glucose intolerance with first diagnosis during pregnancy; it affects 3-10% of pregnancies. The presence of diabetes-related autoantibodies has shown to be able to predict the development of type 1 diabetes before hyperglycemia arises.
To recognize the prevalence of islet cell antibodies among a sample of Egyptian females with gestational diabetes and its possible relation to development of Type 1 diabetes within one year postpartum.
Our cross sectional study was conducted on 150 Egyptian pregnant females with gestational diabetes aged 19-39 years diagnosed by 75-g 2-hour oral glucose tolerance test. All females were subjected to full history, thorough clinical examination and laboratory measurement of anti-islet cell antibodies. Those females with positive antibodies were followed up six months and one year after delivery for their fasting insulin, fasting blood glucose and two hours post prandial glucose levels.
The prevalence of pregnant females with gestational diabetes having positive anti islet cell antibodies was (44%), the prevalence of females diagnosed to have diabetes mellitus was (37.88%) six months and (51.52%) one year postpartum.
The high prevalence of ICAs among pregnant Egyptian females with GDM and the risk of developing type 1diabetes later in life makes screening for ICA among women with GDM important to recognize those at risk of developing type 1 diabetes later in life.
妊娠期糖尿病是指孕期首次诊断出的任何程度的葡萄糖不耐受；它影响3%至10%的妊娠。糖尿病相关自身抗体的存在已被证明能够在高血糖出现之前预测1型糖尿病的发生。
了解埃及妊娠期糖尿病女性样本中胰岛细胞抗体的患病率及其与产后一年内1型糖尿病发生的可能关系。
我们对150名年龄在19至39岁之间、经75克2小时口服葡萄糖耐量试验诊断为妊娠期糖尿病的埃及孕妇进行了横断面研究。所有女性均接受了全面病史、详细临床检查及抗胰岛细胞抗体的实验室检测。抗体呈阳性的女性在分娩后6个月和1年时接受随访，检测其空腹胰岛素、空腹血糖及餐后2小时血糖水平。
妊娠期糖尿病孕妇中抗胰岛细胞抗体呈阳性的患病率为44%，产后6个月被诊断为糖尿病的女性患病率为37.88%，产后1年为51.52%。
埃及妊娠期糖尿病孕妇中胰岛细胞抗体的高患病率以及日后发生1型糖尿病的风险使得对妊娠期糖尿病女性进行胰岛细胞抗体筛查对于识别日后有发生1型糖尿病风险的人群很重要。
