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他达拉非长期给药改善无微生物性MAGI患者症状：一项开放性研究。

Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study.

作者信息

La Vignera Sandro, Condorelli Rosita A, Mongioi Laura M, Calogero Aldo E

机构信息

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

出版信息

Int J Endocrinol. 2017;2017:3848545. doi: 10.1155/2017/3848545. Epub 2017 Mar 30.

DOI:10.1155/2017/3848545
PMID:28465683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5390646/
Abstract

Aim of this study was to evaluate the effects of pharmacological treatment with Tadalafil 5 mg daily on symptoms and quality of sperm parameters in selected patients with amicrobic MAGI (male accessory gland inflammation). 120 patients with amicrobic MAGI (mean age 27.0 ± 6.0 years) with mild-moderate ED (erectile dysfunction) according to IIEF-5 (International Index of Erectile Function 5 Items) scores underwent pharmacological treatment with Tadalafil 5 mg daily for six months. Before and after treatment these patients were evaluated through IIEF-5, semen analysis (according to WHO Criteria, 2010), SI-MAGI (Structured Interview about Male Accessory Gland Inflammation), and ultrasound evaluation. Patients with PVE (prostate-vesciculo-epididymitis) showed a significant increase in the percentage of spermatozoa with total (16.0 ± 8.0 versus 30.0 ± 6.0%) and progressive motility (8.00 ± 10.0 versus 25.0 ± 6.00%). It was a significant reduction of the number of patients with complicated ultrasound forms (30.0 versus 52.0) and a significant increase of the number of patients with uncomplicated ultrasound form (90.0 versus 68.0). Finally, there was a significant reduction in the percentage of patients with alterations of sexual function different from DE, such as premature ejaculation (4.00 versus 8.00%), painful ejaculation (4.00 versus 10.0%), delayed ejaculation (12.50 versus 8.00%), and decreased libido (10.0 versus 25.0%).

摘要

本研究的目的是评估每日服用5毫克他达拉非进行药物治疗对部分无微生物感染的男性附属腺炎（MAGI）患者的症状及精子参数质量的影响。120例根据国际勃起功能指数5项（IIEF-5）评分患有轻度至中度勃起功能障碍（ED）的无微生物感染的MAGI患者（平均年龄27.0±6.0岁）接受了为期6个月的每日5毫克他达拉非药物治疗。在治疗前后，通过IIEF-5、精液分析（根据2010年世界卫生组织标准）、男性附属腺炎结构化访谈（SI-MAGI）和超声评估对这些患者进行了评估。患有前列腺-精囊-附睾炎（PVE）的患者精子总数（16.0±8.0%对30.0±6.0%）和进行性运动能力（8.00±10.0对25.0±6.00%）的百分比显著增加。超声复杂形式的患者数量显著减少（30.0对52.0），超声简单形式的患者数量显著增加（90.0对68.0）。最后，除勃起功能障碍（DE）外的性功能改变患者百分比显著降低，如早泄（4.00%对8.00%）、射精疼痛（4.00%对10.0%）、射精延迟（12.50%对8.00%）和性欲减退（10.0%对25.0%）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f56/5390646/68ddd186b0c0/IJE2017-3848545.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f56/5390646/68ddd186b0c0/IJE2017-3848545.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f56/5390646/68ddd186b0c0/IJE2017-3848545.001.jpg

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本文引用的文献

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Urol Int. 2017;98(2):210-214. doi: 10.1159/000445839. Epub 2016 May 4.
2
Histopathologic and Ultrastructural Changes in Seminiferous Tubules of Adult Male Albino Rats Following Daily Administration of Different Doses of Tadalafil.成年雄性白化大鼠每日给予不同剂量他达拉非后曲细精管的组织病理学和超微结构变化
Urology. 2016 Apr;90:89-96. doi: 10.1016/j.urology.2015.12.038. Epub 2016 Jan 6.
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Once-a-day Tadalafil administration improves the spermogram parameters in fertile patients.
每日一次服用他达拉非可改善可育患者的精液参数。
Arch Ital Urol Androl. 2015 Sep 30;87(3):210-3. doi: 10.4081/aiua.2015.3.210.
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Asian J Androl. 2016 Sep-Oct;18(5):769-72. doi: 10.4103/1008-682X.155539.
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Daily phosphodiesterase type 5 inhibitor therapy: a new treatment option for prostatitis/prostatodynia?每日5型磷酸二酯酶抑制剂疗法：前列腺炎/前列腺痛的一种新治疗选择？
BJU Int. 2014 May;113(5):694-5. doi: 10.1111/bju.12681.
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[Painful ejaculation].[射精疼痛]
Prog Urol. 2014 Jun;24(7):414-20. doi: 10.1016/j.purol.2013.11.008. Epub 2013 Dec 9.
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Effects of 12 weeks of tadalafil treatment on ejaculatory and orgasmic dysfunction and sexual satisfaction in patients with mild to severe erectile dysfunction: integrated analysis of 17 placebo-controlled studies.12 周他达拉非治疗对轻至重度勃起功能障碍患者射精和 orgasmic 功能障碍及性满意度的影响：17 项安慰剂对照研究的综合分析。
BJU Int. 2013 Feb;111(2):334-43. doi: 10.1111/j.1464-410X.2012.11656.x.
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