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Is levothyroxine requirement the same for tablet and soft gel formulations?

作者信息

Di Donna Vincenzo, Paragliola Rosa Maria, de Waure Chiara, Papi Giampaolo, Pontecorvi Alfredo, Corsello Salvatore Maria

机构信息

Unit of Endocrinology, Università Cattolica del Sacro Cuore, largo Agostino Gemelli 8, 00168, Rome, Italy.

Institute of Public Health, Università Cattolica del Sacro Cuore, largo Agostino Gemelli 8, 00168, Rome, Italy.

出版信息

Endocrine. 2018 Feb;59(2):458-460. doi: 10.1007/s12020-017-1311-8. Epub 2017 May 2.

DOI:10.1007/s12020-017-1311-8
PMID:28466401
Abstract
摘要

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Is levothyroxine requirement the same for tablet and soft gel formulations?左甲状腺素片剂和软胶囊制剂的需求量相同吗？
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The administration of L-thyroxine as soft gel capsule or liquid solution.左甲状腺素的给药途径可以是软胶囊或液体制剂。
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Endocrine. 2025 Aug 8. doi: 10.1007/s12020-025-04375-9.
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ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism.ETA关于左甲状腺素钠制剂在单一疗法中用于优化甲状腺功能减退症治疗的指南。
Eur Thyroid J. 2025 Jul 31;14(4). doi: 10.1530/ETJ-25-0123. Print 2025 Aug 1.
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本文引用的文献

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Thyroid Function and Sudden Cardiac Death: A Prospective Population-Based Cohort Study.甲状腺功能与心源性猝死：一项基于人群的前瞻性队列研究。
Circulation. 2016 Sep 6;134(10):713-22. doi: 10.1161/CIRCULATIONAHA.115.020789.
2
Liquid and softgel levothyroxine use in clinical practice: state of the art.临床实践中左甲状腺素液体制剂和软胶囊制剂的应用：现状
Endocrine. 2016 Oct;54(1):3-14. doi: 10.1007/s12020-016-1035-1. Epub 2016 Jul 29.
3
Comparative study between the effects of replacement therapy with liquid and tablet formulations of levothyroxine on mood states, self-perceived psychological well-being and thyroid hormone profile in recently thyroidectomized patients.
左甲状腺素软胶体制剂的剂量-TSH 反应效果分析。
Front Endocrinol (Lausanne). 2024 Feb 21;15:1340204. doi: 10.3389/fendo.2024.1340204. eCollection 2024.
4
Levothyroxine: Conventional and Novel Drug Delivery Formulations.左甲状腺素：常规和新型药物制剂。
Endocr Rev. 2023 May 8;44(3):393-416. doi: 10.1210/endrev/bnac030.
5
Pharmacokinetics and Clinical Implications of Two Non-Tablet Oral Formulations of L-Thyroxine in Patients with Hypothyroidism.左旋甲状腺素两种非片剂口服制剂在甲状腺功能减退患者中的药代动力学及临床意义
J Clin Med. 2022 Jun 16;11(12):3479. doi: 10.3390/jcm11123479.
6
Precision Medicine in Autoimmune Thyroiditis and Hypothyroidism.自身免疫性甲状腺炎和甲状腺功能减退症中的精准医学
Front Pharmacol. 2021 Nov 17;12:750380. doi: 10.3389/fphar.2021.750380. eCollection 2021.
7
The Stability of TSH, and Thyroid Hormones, in Patients Treated With Tablet, or Liquid Levo-Thyroxine.服用片剂或液体制剂左甲状腺素钠的患者 TSH 和甲状腺激素的稳定性。
Front Endocrinol (Lausanne). 2021 Mar 10;12:633587. doi: 10.3389/fendo.2021.633587. eCollection 2021.
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L-T4 Therapy in Enteric Malabsorptive Disorders.肠吸收不良性疾病的 L-T4 治疗。
Front Endocrinol (Lausanne). 2021 Feb 23;12:626371. doi: 10.3389/fendo.2021.626371. eCollection 2021.
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Front Endocrinol (Lausanne). 2021 Jan 29;11:626268. doi: 10.3389/fendo.2020.626268. eCollection 2020.
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Case Rep Endocrinol. 2020 Sep 5;2020:8858887. doi: 10.1155/2020/8858887. eCollection 2020.
左甲状腺素液体剂型与片剂剂型替代疗法对近期甲状腺切除患者情绪状态、自我感知心理健康及甲状腺激素谱影响的比较研究
Endocrine. 2017 Jan;55(1):51-59. doi: 10.1007/s12020-016-1003-9. Epub 2016 Jul 7.
4
Thyroid Hormone Profile in Patients Ingesting Soft Gel Capsule or Liquid Levothyroxine Formulations with Breakfast.早餐时服用软胶囊或液体左甲状腺素制剂的患者的甲状腺激素谱
Int J Endocrinol. 2016;2016:9043450. doi: 10.1155/2016/9043450. Epub 2016 May 30.
5
Treatment of hypothyroidism: all that glitters is gold?甲状腺功能减退症的治疗：闪光的都是金子吗？
Endocrine. 2016 Jun;52(3):411-3. doi: 10.1007/s12020-016-0882-0. Epub 2016 Feb 29.
6
Levothyroxine soft capsules demonstrate bioequivalent pharmacokinetic exposure with the European reference tablets in healthy volunteers under fasting conditions.左甲状腺素软胶囊在空腹条件下，对健康志愿者进行的药代动力学研究表明，其与欧洲参比片剂具有生物等效性。
Int J Clin Pharmacol Ther. 2016 Feb;54(2):135-43. doi: 10.5414/CP202485.
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Oral L-thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study.左甲状腺素口服液与片剂用于无吸收不良的甲状腺功能减退患者：一项前瞻性研究。
Endocrine. 2016 Jun;52(3):597-601. doi: 10.1007/s12020-015-0836-y. Epub 2015 Dec 31.
8
Thyroxine softgel capsule in patients with gastric-related T4 malabsorption.甲状腺素软胶囊用于治疗与胃相关的T4吸收不良患者。
Endocrine. 2015 May;49(1):51-7. doi: 10.1007/s12020-014-0476-7. Epub 2015 Jan 17.
9
A new strategy to estimate levothyroxine requirement after total thyroidectomy for benign thyroid disease.一种用于估计良性甲状腺疾病全甲状腺切除术后左甲状腺素需求量的新策略。
Thyroid. 2014 Dec;24(12):1759-64. doi: 10.1089/thy.2014.0111.
10
The administration of L-thyroxine as soft gel capsule or liquid solution.左甲状腺素的给药途径可以是软胶囊或液体制剂。
Expert Opin Drug Deliv. 2014 Jul;11(7):1103-11. doi: 10.1517/17425247.2014.918101. Epub 2014 Jun 4.