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同种异体移植物和异种移植物用于牙槽嵴保存的比较。一项在人类中进行的临床和组织形态计量 RCT。

Comparison of allografts and xenografts used for alveolar ridge preservation. A clinical and histomorphometric RCT in humans.

机构信息

Department of Basic Science and Oral Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.

Center for Dental Medicine, University of Zurich, Zurich, Switzerland.

出版信息

Clin Implant Dent Relat Res. 2017 Aug;19(4):608-615. doi: 10.1111/cid.12490. Epub 2017 May 2.

Abstract

BACKGROUND

Several types of bone grafts are used in ridge preservation procedures.

PURPOSE

To compare the healing of allografts and xenografts applied for alveolar ridge preservation.

MATERIALS AND METHODS

Twenty volunteers in need of extraction of a single-rooted tooth prior to implant installation were randomized into two groups. One group received a deproteinized cancellous bovine bone xenograft embedded in a 10% collagen matrix and the other a demineralized freeze-dried cortical bone allograft. A collagen membrane was used to cover the grafts, flaps were sutured. At baseline and 6 months later, clinical measurements including vertical and horizontal bone dimensions were taken. Histomorphometric analysis was performed.

RESULTS

Both groups showed shrinkage of bone dimensions. At mesial, center and distal sites, the vertical changes in dimension were -0.6, 0.5, and -0.1 mm for the allograft and -1.1, -0.4, and -0.9 mm for the xenograft. The horizontal changes in dimensions were -1.4 mm for the allograft and -2.6 mm for the xenograft. New bone and residual graft material were 25.5 ± 10.1% and 33.8 ± 9.4% at the allograft and 35.3 ± 16.8% and 22.2 ± 13.4% at the xenograft sites. None of the differences was statistically significant.

CONCLUSION

Both grafting materials are suitable for the preservation of the alveolar ridge.

摘要

背景

在牙槽嵴保存术中使用了几种类型的骨移植物。

目的

比较同种异体移植物和异种移植物在牙槽嵴保存中的愈合情况。

材料和方法

20 名志愿者因需要在植入物安装前拔除单根牙齿而被随机分为两组。一组接受脱蛋白松质牛骨异种移植物嵌入 10%胶原基质,另一组接受脱矿冻干皮质骨同种异体移植物。使用胶原膜覆盖移植物,缝合皮瓣。在基线和 6 个月后,进行了包括垂直和水平骨尺寸在内的临床测量。进行了组织形态计量学分析。

结果

两组均显示出骨尺寸的收缩。在近中、中央和远中部位,同种异体移植物的垂直尺寸变化为-0.6、0.5 和-0.1 毫米,异种移植物为-1.1、-0.4 和-0.9 毫米。水平尺寸的变化在同种异体移植物为-1.4 毫米,在异种移植物为-2.6 毫米。同种异体移植物的新骨和残留移植物材料分别为 25.5±10.1%和 33.8±9.4%,异种移植物分别为 35.3±16.8%和 22.2±13.4%。这些差异均无统计学意义。

结论

两种移植物材料均适用于牙槽嵴的保存。

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