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采用牙髓显微外科手术及双相硫酸钙材料移植治疗下颌骨骨化纤维瘤:病例报告

Treatment of an ossifying fibroma of the mandible with endodontic microsurgery and grafting with a biphasic calcium sulfate material: a case report.

作者信息

Dudeck Damian, Warmusz Oliwia, Reichman-Warmusz Edyta, Kurtzman Gregori M

机构信息

"Artmedica" Ambulatory Oral Surgery and Implantology, Thorn.

Department of Histology and Cell Pathology in Zabrze, School of Medicine with the Division of Dentistry, Medical University of Silesia in Katowice.

出版信息

Ann Med Surg (Lond). 2023 Jul 15;85(8):4167-4173. doi: 10.1097/MS9.0000000000001068. eCollection 2023 Aug.

Abstract

UNLABELLED

A significant percentage of lesions of endodontic origin require surgical management due to the possible diagnosis of odontogenic cysts and tumors in the maxilla and mandible. Ossifying fibroma is a benign fibro-osseous lesion that typically presents as a painless, slow-growing, and expansile lesion that appears as a well-demarcated lesion with a variable degree of internal calcification on radiography. Treatment results in a large osseous defect, utilization of a graft to fill the void accelerates healing and prevents complications that may result from failure to fill by the host response.

CASE PRESENTATION

Following endodontic surgery placement of osseous graft material via Guided Tissue Regeneration to fill the defect aids to accelerate fill of the defect on a healthy 26-year-old female patient. A case discussing the one-step treatment of an ossifying fibroma of the anterior part of the mandible following endodontic microsurgery with associated retrograde fill of the apex, then site grating with biphasic calcium sulfate (Bond Apatite) used in regeneration of the osseous defect related to the lesion and resulting surgery.

CLINICAL DISCUSSION

Histologically, the ossifying fibroma is dominated by connective tissue containing cell rich areas with a few fragments of fibrosis. Moreover, in the connective tissue numerous small fragments of spongy and compact bone with areas of partial necrosis present and a significant number of inflammatory cells are observed. Surgical removal of the cyst with thorough curettage of the osseous walls and grafting of the defect provides predictable healing and the desired clinical results sought. Utilization of the biphasic calcium sulfate graft material allows the elimination of the need to overlay the area with a membrane before the flap due to its hard set and the prevention of soft tissue ingrowth into the graft material during the healing phase. Additionally, the hard set of the material allows tenting of the area to maintain the desired volume and ridge contour. Conversion of the graft material depending on the volume placed to host bone occurs over a 3-6 month period.

CONCLUSION

The case report presented, as well as the authors experience mimics the literature on biphasic calcium sulfate in its use as an osseous graft material and is an effective method for the repair of osseous defects that result from the removal of tumors and cysts of the maxilla and mandible. Treatment of an ossifying fibroma is an ideal application of the use of this biphasic calcium sulfate material allowing tenting of the surgical site over the defect created after cyst removal without the need for resorbable collagen membranes. This simplifies its use and decreases material costs that may hamper patient acceptance of treatment without a decrease in expected clinical results.

摘要

未标注

由于上颌骨和下颌骨中可能诊断出牙源性囊肿和肿瘤,相当一部分源于牙髓病的病变需要手术治疗。骨化性纤维瘤是一种良性纤维-骨性病变,通常表现为无痛、生长缓慢的膨胀性病变,在影像学上表现为边界清晰的病变,内部有不同程度的钙化。治疗会导致较大的骨缺损,使用移植物填充空隙可加速愈合并预防因宿主反应无法填充而可能导致的并发症。

病例介绍

在牙髓手术后,通过引导组织再生放置骨移植材料来填充缺损,这有助于加速一名健康的26岁女性患者缺损的填充。该病例讨论了下颌骨前部骨化性纤维瘤的一步治疗方法,包括牙髓显微手术后根尖的逆行充填,然后用双相硫酸钙(骨磷灰石)进行位点植骨,用于与病变相关的骨缺损的再生及后续手术。

临床讨论

从组织学上看,骨化性纤维瘤以结缔组织为主,结缔组织中有富含细胞的区域以及一些纤维化碎片。此外,在结缔组织中可见许多海绵状和致密骨的小碎片,伴有部分坏死区域,并且观察到大量炎性细胞。手术切除囊肿并彻底刮除骨壁,然后对缺损进行植骨,可实现可预测的愈合和预期的临床效果。使用双相硫酸钙移植材料,由于其硬结特性,无需在翻瓣前用膜覆盖该区域,并且在愈合阶段可防止软组织长入移植材料中。此外,材料的硬结可使该区域隆起,以维持所需的体积和牙槽嵴轮廓。移植材料根据植入的体积在3至6个月内转化为宿主骨。

结论

所呈现的病例报告以及作者的经验与关于双相硫酸钙作为骨移植材料的文献相符,是修复因上颌骨和下颌骨肿瘤及囊肿切除导致的骨缺损的有效方法。骨化性纤维瘤的治疗是使用这种双相硫酸钙材料的理想应用,可使手术部位在囊肿切除后形成的缺损上方隆起,而无需使用可吸收胶原膜。这简化了其使用并降低了材料成本,而不会降低预期的临床效果,否则可能会妨碍患者接受治疗。

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