Randhawa Puneet Kaur, Jaggi Amteshwar Singh
1 Department of Pharmaceutical Sciences and Drug Research, Punjabi University Patiala, Patiala, Punjab, India.
J Cardiovasc Pharmacol Ther. 2018 Jan;23(1):38-45. doi: 10.1177/1074248417707050. Epub 2017 May 3.
Besides functioning as thermosensors, transient receptor potential vanilloid 1 (TRPV) channels play a pivotal role in ischemia-reperfusion injury. Transient receptor potential vanilloid 1 channel activation attenuates ischemia-reperfusion-induced injury in various organs including the heart, lungs, kidneys, and the brain. Transient receptor potential vanilloid 1 channels are expressed on the sensory neurons innervating the myocardium, ventricles of the heart, epicardial surface of the heart, endothelial cells, and the vascular smooth muscle cells. During ischemic conditions, activation of TRPV channels on the perivascular nerves stimulates the release of calcitonin gene-related peptide and substance P to produce cardioprotection. Furthermore, TRPV channel activation reduces the generation of free radicals and inflammatory cytokines, inhibits neutrophil infiltration, and enhances the production of anti-inflammatory cytokines to reduce ischemia-reperfusion-induced tissue injury. The present review describes the potential involvement of TRPV channels and the signaling cascade in attenuating ischemia-reperfusion injury in various organs.
除了作为温度感受器发挥作用外，瞬时受体电位香草酸亚型1（TRPV）通道在缺血再灌注损伤中起关键作用。瞬时受体电位香草酸亚型1通道的激活可减轻包括心脏、肺、肾脏和大脑在内的各种器官的缺血再灌注损伤。瞬时受体电位香草酸亚型1通道表达于支配心肌、心脏心室、心脏心外膜表面、内皮细胞和血管平滑肌细胞的感觉神经元上。在缺血状态下，血管周围神经上的TRPV通道激活会刺激降钙素基因相关肽和P物质的释放，从而产生心脏保护作用。此外，TRPV通道激活可减少自由基和炎性细胞因子的生成，抑制中性粒细胞浸润，并增强抗炎细胞因子的产生，以减轻缺血再灌注诱导的组织损伤。本综述描述了TRPV通道和信号级联在减轻各种器官缺血再灌注损伤中的潜在作用。
