Li H L, Ru K, Sun Q, Li Z Q, Zhang H J, Ma Y, Xian M, Qiu L G, Liu E B
Department of Pathology, Department of Lymphoma & Myeloma, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union of Medical College, Tianjin 300020, China.
Zhonghua Bing Li Xue Za Zhi. 2017 May 8;46(5):327-331. doi: 10.3760/cma.j.issn.0529-5807.2017.05.009.
To study the clinicopathologic features of plasma cell myeloma(PCM) with bone marrow fibrosis (MF). The clinicopathologic data of 175 cases of newly diagnosed PCM patients were retrospectively analyzed. Based on reticular fiber staining, these cases were divided into PCM-MF and non-PCM-MF groups. Sixty-three cases were PCM-MF(36%), 112 were non-PCM-MF (64%). No statistical difference in gender, age, hemoglobin level, platelet counts, the classification of immunoglobulin, ISS staging, immunohistochemical phenotypes and genetic features was found between PCM-MF and non-PCM-MF groups (>0.05). Compared to non-PCM-MF group, lactate dehydrogenase (LDH)level and renal impairmentrate were higher in PCM-MF group (<0.05). The degree of bone marrow hyperplasia, the percentage of myeloma cells and cells with plasmablastic morphology were significantly higher in PCM-MF group(<0.05). The higher LDH level, renal impairment rate, and more significant bone marrow hyperplasia, proliferation of plasma cells and plasmablastic myeloma cells infiltration indicate poor prognosis of PCM-MF patients.
研究伴有骨髓纤维化（MF）的浆细胞骨髓瘤（PCM）的临床病理特征。回顾性分析175例新诊断的PCM患者的临床病理资料。根据网状纤维染色，将这些病例分为PCM-MF组和非PCM-MF组。PCM-MF组63例（36%），非PCM-MF组112例（64%）。PCM-MF组与非PCM-MF组在性别、年龄、血红蛋白水平、血小板计数、免疫球蛋白分类、国际分期系统（ISS）分期、免疫组化表型及遗传学特征方面均无统计学差异（>0.05）。与非PCM-MF组相比，PCM-MF组乳酸脱氢酶（LDH）水平及肾功能损害率更高（<0.05）。PCM-MF组骨髓增生程度、骨髓瘤细胞百分比及浆母细胞形态细胞百分比显著更高（<0.05）。较高的LDH水平、肾功能损害率以及更显著的骨髓增生、浆细胞增殖和浆母细胞骨髓瘤细胞浸润提示PCM-MF患者预后较差。
