青少年和成人无烟烟草角化病中人类乳头瘤病毒衣壳抗原的形态学和免疫组化证据

Morphologic and immunohistochemical evidence of human papillomavirus capsid antigen in smokeless tobacco keratoses from juveniles and adults.

作者信息

Greer R O, Schroeder K L, Crosby L

机构信息

Division of Oral Pathology and Oncology, University of Colorado School of Dentistry, Denver 80262.

出版信息

J Oral Maxillofac Surg. 1988 Nov;46(11):919-29. doi: 10.1016/0278-2391(88)90327-8.

DOI:10.1016/0278-2391(88)90327-8

PMID:2846804

Abstract

Seventy-seven tissue samples from patients with either degree I, II, or III smokeless tobacco keratoses were examined. The tissues were evaluated for the presence of human papillomavirus (HPV) antigen by immunocytochemical staining. Capsid antigen could be identified in sixteen cases (20.78%). This investigation further supports the concept that smokeless tobacco-associated leukoplakias can be correlated with HPV infection.

摘要

对77例患有I度、II度或III度无烟烟草角化病患者的组织样本进行了检查。通过免疫细胞化学染色评估组织中是否存在人乳头瘤病毒（HPV）抗原。在16例（20.78%）病例中可识别出衣壳抗原。这项研究进一步支持了无烟烟草相关白斑可能与人乳头瘤病毒感染有关的观点。