Kang W Y, Tian Z Y, Li Q F, Zhang L F, Xu L
Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Apr 10;38(4):518-521. doi: 10.3760/cma.j.issn.0254-6450.2017.04.021.
Through two nationwide sero-epidemiological survey programs on hepatitis B virus (HBV), hepatitis B markers in Yunnan province were compared between the findings in 2014 and in 2006. Results were used to understand the HBV epidemic status in Yunnan province and to estimate the efficiency of measures on prevention and control of the disease. People at the age of 1-29 years were sampled from 6 counties of the National Disease Surveillance sites in Yunnan province, by multi-stage random sampling method. Demographic information was collected by questionnaire, and 2-4 ml serum sample was taken to detect HBsAg, anti-HBs, anti-HBc, HBeAg and anti-HBe, by ELISA method. were logged-in the database and analyzed by SPSS 17.0. Results Between the two studies, no statistically significant differences were observed on the overall HBV infection rates and the positive rates of HBsAg, HBeAg, anti-HBe, anti-HBc. Positive rate of anti-HBs in 2014 was significantly higher than that in 2006. The main two combination profiles of hepatitis B markers were through the fifth model which was positive only for anti-HBs and the sixth model which was negative for all markers in 2006, and the same in 2014. Detection rate through the fifth profile in 2014 was significantly higher than the rate in 2006, while the detection rate of the sixth profile in 2014 was significantly lower than the one in 2006. When analyzing the differences in the same age group, between the two surveys, results showed that the positive rate of anti-HBs in 2014 was significantly higher than that in 2006, in both the10-14 and the 15-19 years-old groups. Positive rate of anti-HBc in the 20-29 year-olds in 2014 was significantly lower than the one of 2006. The positive rates of HBsAg in the age groups of 1-4, 5-14 and 15-29 were 1.12,1.61 and 1.25 respectively, in 2014. Prevention and control measures on HBV seemed in great progres. However, more effective prevention and control measures should be taken continually among people under the age of 15, in Yunnan province.
通过两项全国性的乙型肝炎病毒（HBV）血清流行病学调查项目，对云南省2014年和2006年的乙肝标志物检测结果进行了比较。结果用于了解云南省HBV的流行状况，并评估该疾病的预防和控制措施的效果。采用多阶段随机抽样方法，从云南省国家疾病监测点的6个县抽取1-29岁的人群。通过问卷调查收集人口统计学信息，并采集2-4ml血清样本，采用酶联免疫吸附测定法（ELISA）检测HBsAg、抗-HBs、抗-HBc、HBeAg和抗-HBe。数据录入数据库，并用SPSS 17.0进行分析。结果在两项研究之间，总体HBV感染率以及HBsAg、HBeAg、抗-HBe、抗-HBc的阳性率均未观察到统计学上的显著差异。2014年抗-HBs的阳性率显著高于2006年。乙肝标志物的主要两种组合模式在2006年和2014年都是第五种模式（仅抗-HBs阳性）和第六种模式（所有标志物均为阴性）。2014年通过第五种模式的检测率显著高于2006年，而2014年第六种模式的检测率显著低于2006年。在分析同一年龄组的差异时，两项调查结果显示，在10-14岁和15-19岁年龄组中，2014年抗-HBs的阳性率均显著高于2006年。2014年20-29岁年龄组抗-HBc的阳性率显著低于2006年。2014年1-4岁、5-14岁和15-29岁年龄组的HBsAg阳性率分别为1.12、1.61和1.25。HBV的预防和控制措施似乎取得了很大进展。然而，云南省15岁以下人群仍应持续采取更有效的预防和控制措施。
