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[Effects of decitabine on proliferation capacity and TFPI-2 expression in leukemia K562 cells].

作者信息

Wang F J, Li J J, Xie H T, Zeng Y Y, Liu J, Zhang J

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2017 Apr 14;38(4):340-343. doi: 10.3760/cma.j.issn.0253-2727.2017.04.016.

DOI:10.3760/cma.j.issn.0253-2727.2017.04.016
PMID:28468099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7342715/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/c8a8ea42809d/cjh-38-04-340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/789e9bce38c8/cjh-38-04-340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/c9bd21d348d6/cjh-38-04-340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/44be3950668d/cjh-38-04-340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/e6ff125837b7/cjh-38-04-340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/c8a8ea42809d/cjh-38-04-340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/789e9bce38c8/cjh-38-04-340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/c9bd21d348d6/cjh-38-04-340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/44be3950668d/cjh-38-04-340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/e6ff125837b7/cjh-38-04-340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0445/7342715/c8a8ea42809d/cjh-38-04-340-g005.jpg

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1
[Effects of decitabine on proliferation capacity and TFPI-2 expression in leukemia K562 cells].[地西他滨对白血病K562细胞增殖能力及TFPI-2表达的影响]
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2
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Decitabine has a biphasic effect on natural killer cell viability, phenotype, and function under proliferative conditions.地西他滨在增殖条件下对自然杀伤细胞活力、表型和功能具有双相作用。
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Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation.地西他滨，一种 DNA 甲基转移酶抑制剂，通过细胞内活性氧的产生诱导人白血病细胞凋亡。
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The differentiating and apoptotic effects of 2-aza-5'-deoxycytidine are dependent on the PU.1 expression level in PU.1-transgenic K562 cells.2-氮杂-5'-脱氧胞苷的分化和凋亡作用依赖于 PU.1 转基因 K562 细胞中 PU.1 的表达水平。
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TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma.TFPI-2 是一个假定的肿瘤抑制基因，在鼻咽癌中常因启动子超甲基化而失活。
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本文引用的文献

1
The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma.DNA甲基化在人食管鳞状细胞癌中的诊断、预后及预测价值。
Clin Epigenetics. 2016 Apr 22;8:43. doi: 10.1186/s13148-016-0210-9. eCollection 2016.
2
TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells.TESTIN可诱导儿童B系急性淋巴细胞白血病细胞快速死亡并抑制其增殖。
PLoS One. 2016 Mar 17;11(3):e0151341. doi: 10.1371/journal.pone.0151341. eCollection 2016.
3
DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.
B细胞成熟过程中的DNA甲基化动态变化是慢性淋巴细胞白血病一系列疾病表型的基础。
Nat Genet. 2016 Mar;48(3):253-64. doi: 10.1038/ng.3488. Epub 2016 Jan 18.
4
Epigenetic Therapy in Acute Myeloid Leukemia: Current and Future Directions.急性髓系白血病的表观遗传治疗：现状与未来方向
Semin Hematol. 2015 Jul;52(3):172-83. doi: 10.1053/j.seminhematol.2015.04.003. Epub 2015 Apr 8.
5
Hypermethylation of TFPI2 correlates with cervical cancer incidence in the Uygur and Han populations of Xinjiang, China.组织因子途径抑制物2（TFPI2）的高甲基化与中国新疆维吾尔族和汉族人群的宫颈癌发病率相关。
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1844-54. eCollection 2015.
6
Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma.甲基化诱导的TFPI-2下调导致TMPRSS4过表达，并在一部分非小细胞肺癌中促进肿瘤发生。
Cancer Sci. 2015 Jan;106(1):34-42. doi: 10.1111/cas.12569. Epub 2014 Dec 8.
7
[Expression of TFPI-2 gene and its promoter methylation in acute myeloid leukemia].[组织因子途径抑制物-2基因及其启动子甲基化在急性髓系白血病中的表达]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Aug;22(4):920-6. doi: 10.7534/j.issn.1009-2137.2014.04.008.
8
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.成人新发急性髓系白血病的基因组和表观基因组图谱。
N Engl J Med. 2013 May 30;368(22):2059-74. doi: 10.1056/NEJMoa1301689. Epub 2013 May 1.
9
Methylation of TFPI-2 is an early event of esophageal carcinogenesis.TFPI-2 的甲基化是食管癌变的早期事件。
Epigenomics. 2012 Apr;4(2):135-46. doi: 10.2217/epi.12.11.
10
Adenovirus-mediated gene transfer of tissue factor pathway inhibitor-2 inhibits gallbladder carcinoma growth in vitro and in vivo.腺病毒介导的组织因子途径抑制剂-2 基因转移抑制胆囊癌细胞在体内外的生长。
Cancer Sci. 2012 Apr;103(4):723-30. doi: 10.1111/j.1349-7006.2012.02218.x. Epub 2012 Mar 4.