Agrawal Ranjan, Mohan Nitesh, Bisht Mithila, Kumar Parbodh
Department of Pathology, Rohilkhand Medical College Hospital, Bareilly, Uttar Pradesh, India.
J Cytol. 2017 Apr-Jun;34(2):110-112. doi: 10.4103/0970-9371.203572.
Papillary lesions of the breast pose great diagnostic challenges on fine needle aspiration cytology (FNAC) due to overlapping features between benign and malignant entities. Preoperative cytodiagnosis is difficult. We present a case of a 52-year-old male who presented with a progressively increasing firm swelling in the left breast for 3 years. The nipple was eroded with ulceration and bleeding. Ultrasonography (USG) revealed a mass measuring 2.9 cm × 1.5 cm in the left breast. FNAC smears were hypercellular with ductal cells arranged in papillae and glandular clusters. At places, the cells had irregular nuclear membrane, prominent nucleoli, fine chromatin, scanty-to-moderate cytoplasm, and high nuclear-cytoplasmic ratio with pleomorphism. Histopathology of the excised swelling was consistent with intracystic papillary carcinoma (IPC) supported with immunohistochemistry markers. The case is being presented due to its rarity.
由于良性和恶性病变之间存在重叠特征，乳腺乳头状病变在细针穿刺细胞学检查（FNAC）中带来了巨大的诊断挑战。术前细胞诊断困难。我们报告一例52岁男性，其左乳出现进行性增大的硬结3年。乳头糜烂、溃疡并出血。超声检查（USG）显示左乳有一大小为2.9 cm×1.5 cm的肿块。FNAC涂片细胞丰富，导管细胞呈乳头状和腺泡状排列。部分区域细胞具有不规则核膜、明显核仁、细染色质、少量至中等量细胞质以及核质比高伴多形性。切除肿物的组织病理学检查结果与囊内乳头状癌（IPC）相符，并得到免疫组化标记物支持。因其罕见性，故报告此病例。
