抑制自噬可通过增强紫杉醇诱导的半胱天冬酶依赖性凋亡来逆转鼻咽癌对紫杉醇的耐药性。
Inhibition of autophagy results in a reversal of taxol resistance in nasopharyngeal carcinoma by enhancing taxol-induced caspase-dependent apoptosis.
作者信息
Song Yexun, Li Wei, Peng Xiaowei, Xie Jun, Li Heqing, Tan Guolin
机构信息
Department of Otolaryngology-Head Neck Surgery, The Third Xiangya Hospital of Central South UniversityChangsha, Hunan, China.
Department of Head and Neck Surgery and Oncology Plastic Surgery, The Affiliated Cancer Hospital of Xiangya Medical School, Central South UniversityChangsha, Hunan, China.
出版信息
Am J Transl Res. 2017 Apr 15;9(4):1934-1942. eCollection 2017.
Abstract
Drug resistance in nasopharyngeal carcinoma remains a major obstacle of clinical therapy. We found that the taxol-resistant cells demonstrated higher basal levels of autophagy than parental cells, which could be inhibited by 3-MA and Beclin-1-siRNA. We further revealed that inhibition of autophagy enhanced taxol-induced caspase-dependent apoptosis, resulted in partial reversal of the acquired taxol resistance in taxol-resistant cells. Our results suggest that the combination of an autophagy inhibitor with taxol may be a promising approach to promote therapeutic efficacy in patients with nasopharyngeal carcinoma.
摘要
鼻咽癌的耐药性仍然是临床治疗的主要障碍。我们发现，紫杉醇耐药细胞的自噬基础水平高于亲代细胞，这可被3-MA和Beclin-1小干扰RNA抑制。我们进一步揭示，抑制自噬可增强紫杉醇诱导的半胱天冬酶依赖性凋亡，导致紫杉醇耐药细胞获得性紫杉醇耐药的部分逆转。我们的结果表明，自噬抑制剂与紫杉醇联合使用可能是提高鼻咽癌患者治疗效果的一种有前景的方法。
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