急性早幼粒细胞白血病的中枢神经系统受累：三例报告
Central nervous system involvement of acute promyelocytic leukemia, three case reports.
作者信息
Furuya Aya, Kawahara Masahiro, Kumode Mina, Ohira Yasuyuki, Usui Asako, Nagai Shiho, Hosoba Sakura, Minamiguchi Hitoshi, Kito Katsuyuki, Andoh Akira
机构信息
Division of Gastroenterology and Hematology Department of Medicine Shiga University of Medical Science Otsu Japan.
出版信息
Clin Case Rep. 2017 Mar 29;5(5):645-653. doi: 10.1002/ccr3.919. eCollection 2017 May.
Central nervous system (CNS) involvement of acute promyelocytic leukemia (APL) causes poor prognosis. Our three cases show that CNS can be involved at the first hematological recurrence, but predicting this is difficult. Triple intrathecal treatment and craniospinal irradiation were effective, while arsenic oxide failed to prevent and improve CNS involvement.
急性早幼粒细胞白血病（APL）累及中枢神经系统（CNS）会导致预后不良。我们的三例病例显示，CNS可在首次血液学复发时受累，但对此进行预测很困难。三联鞘内注射治疗和全脑全脊髓照射有效，而三氧化二砷未能预防和改善CNS受累情况。
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